4-(4-fluorophenyl)-1-(methoxymethyl)-2-(3,4,5-trimethoxyphenyl)-1H-imidazole

Base Information

Chemical Name:4-(4-fluorophenyl)-1-(methoxymethyl)-2-(3,4,5-trimethoxyphenyl)-1H-imidazole
CAS No.:1346175-01-6
Molecular Formula:C₂₀H₂₁FN₂O₄
Molecular Weight:372.396
Hs Code.:

Synonyms:4-(4-fluorophenyl)-1-(methoxymethyl)-2-(3,4,5-trimethoxyphenyl)-1H-imidazole

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Chemical Property of 4-(4-fluorophenyl)-1-(methoxymethyl)-2-(3,4,5-trimethoxyphenyl)-1H-imidazole

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Technology Process of 4-(4-fluorophenyl)-1-(methoxymethyl)-2-(3,4,5-trimethoxyphenyl)-1H-imidazole

There total 3 articles about 4-(4-fluorophenyl)-1-(methoxymethyl)-2-(3,4,5-trimethoxyphenyl)-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1346175-00-5
4-(4-fluorophenyl)-2-(3,4,5-trimethoxyphenyl)-1H-imidazole

: 107-30-2
chloromethyl methyl ether

: 1346175-01-6
4-(4-fluorophenyl)-1-(methoxymethyl)-2-(3,4,5-trimethoxyphenyl)-1H-imidazole

Guidance literature:: 4-(4-fluorophenyl)-2-(3,4,5-trimethoxyphenyl)-1H-imidazole; With sodium hydride; In tetrahydrofuran; for 0.5h;

chloromethyl methyl ether; In tetrahydrofuran; toluene; at 0 ℃; for 0.5h;
DOI:10.1016/j.tet.2011.09.053

Reference yield:

: 86-81-7
3,4,5-trimethoxy-benzaldehyde

: 1346175-01-6
4-(4-fluorophenyl)-1-(methoxymethyl)-2-(3,4,5-trimethoxyphenyl)-1H-imidazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: ammonium acetate / methanol / 20 °C

2.1: sodium hydride / tetrahydrofuran / 0.5 h

2.2: 0.5 h / 0 °C

With ammonium acetate; sodium hydride; In tetrahydrofuran; methanol;
DOI:10.1016/j.tet.2011.09.053

Reference yield:

: 403-32-7
(4-fluorophenyl)glyoxal

: 1346175-01-6
4-(4-fluorophenyl)-1-(methoxymethyl)-2-(3,4,5-trimethoxyphenyl)-1H-imidazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: ammonium acetate / methanol / 20 °C

2.1: sodium hydride / tetrahydrofuran / 0.5 h

2.2: 0.5 h / 0 °C

With ammonium acetate; sodium hydride; In tetrahydrofuran; methanol;
DOI:10.1016/j.tet.2011.09.053