403-32-7

Basic information

• Product Name: (4-FLUORO-PHENYL)-OXO-ACETALDEHYDE
• Synonyms: 4-fluoro-alpha-oxo-benzeneacetaldehyd;4-fluoro-alpha-oxobenzeneacetaldehyde;4-FLUOROPHENYLGLYOXAL;(4-FLUORO-PHENYL)-OXO-ACETALDEHYDE;4-Fluoro-α-oxo-benzeneacetaldehyde;Benzeneacetaldehyde, 4-fluoro-.alpha.-oxo-;(p-Fluorophenyl)glyoxal;NSC 402742
• CAS NO: 403-32-7
• Molecular Formula: C₈H₅FO₂
• Molecular Weight: 170.14
• Product Categories: Aromatics;Miscellaneous Reagents
• Mol File: 403-32-7.mol
• Article Data: 55

Chemical Properties

• Melting Point: 84-88℃
• Boiling Point: 214.5°Cat760mmHg
• Flash Point: 80.4°C
• Appearance: /
• Density: 1.241g/cm³
• Vapor Pressure: 0.155mmHg at 25°C
• Solubility: Chloroform, Methanol
• CAS DataBase Reference: (4-FLUORO-PHENYL)-OXO-ACETALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: (4-FLUORO-PHENYL)-OXO-ACETALDEHYDE(403-32-7)
• EPA Substance Registry System: (4-FLUORO-PHENYL)-OXO-ACETALDEHYDE(403-32-7)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• RTECS: CY1440000
• Hazardous Substances Data: 403-32-7(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

4-Fluoro-α-oxo-benzeneacetaldehyde (cas# 403-32-7) is a compound useful in organic synthesis.

InChI:InChI=1/C8H5FO2.H2O/c9-7-3-1-6(2-4-7)8(11)5-10;/h1-5H;1H2

Upstream product

• 403-42-9 1-(4-fluorophenyl)ethanone 
• 462-06-6 fluorobenzene 
• 405-99-2 para-fluorostyrene 
• 403-31-6 4-fluoro-2-hydroxy-acetophenone 

Downstream Products

• 81593-29-5 5-(4-fluorophenyl)-1-phenylhydantoin 
• 81593-37-5 5-(4-Fluoro-phenyl)-1-p-tolyl-imidazolidine-2,4-dione 
• 121041-71-2 2-(4-Fluoro-phenyl)-6-(2-methoxy-phenoxy)-imidazo[1,2-b]pyridazin-3-ol 
• 107128-47-2 5-(4-fluorophenyl)-1,2,4-triazin-3-amine 
• 447-43-8 1-(4-fluorophenyl)-2,2-dihydroxyethan-1-one 
• 157429-18-0 C₉H₈FN₃OS 
• 362610-10-4 2,2-difluoro-2-(4-fluorophenyl)acetaldehyde 
• 935479-78-0 2,2-bis-benzyloxy-1-(4-fluoro-phenyl)-ethanone 

Relevant articles and documents

SUBSTITUTED ARYL COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF

The present application relates to a substituted aryl compound or a pharmaceutically acceptable salt, a stereoisomer, a polymorph, a solvate, a N-oxide, an isotope-labeled compound, a metabolite or a prodrug thereof, and a preparation method therefor and use thereof, also relates to a pharmaceutical composition containing the compound and a therapeutic use thereof. The compound or a pharmaceutical composition thereof can inhibit the activity of adenosine A2a receptor, and can be used for treating or preventing a disease related to adenosine A2a receptor, especially for treating a tumor.

Ynonylation of Acyl Radicals by Electroinduced Homolysis of 4-Acyl-1,4-dihydropyridines

Herein we report the conversion of 4-Acyl-1,4-dihydropyridines (DHPs) into ynones under electrochemical conditions. The reaction proceeds via the homolysis of acyl-DHP under electron activation. The resulting acyl radicals react with hypervalent iodine(III) reagents to form the target ynones or ynamides in acceptable yields. This mild reaction condition allows wider functionality tolerance that includes halides, carboxylates, or alkenes. The synthetic utility of this methodology is further demonstrated by the late-stage modification of complex molecules.

1-phenyl-2-phenylaminoethyl ketone derivative and medical application

The invention belongs to the field of pharmaceutical chemicals, and relates to a micromolecular inhibitor of polymyxin drug-resistant protein MCR-1 and application thereof. The invention relates to acompound shown as a formula I, a pharmaceutically accept