3-(4-Hydroxy-2,3,5-trimethyl-phenylsulfanyl)-butyric acid methyl ester

Base Information

• Chemical Name: 3-(4-Hydroxy-2,3,5-trimethyl-phenylsulfanyl)-butyric acid methyl ester
• CAS No.: 101836-22-0
• Molecular Formula: C₁₄H₂₀O₃S
• Molecular Weight: 268.377
• Mol file: 101836-22-0.mol

Synonyms:3-(4-Hydroxy-2,3,5-trimethyl-phenylsulfanyl)-butyric acid methyl ester

Chemical Property of 3-(4-Hydroxy-2,3,5-trimethyl-phenylsulfanyl)-butyric acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-Hydroxy-2,3,5-trimethyl-phenylsulfanyl)-butyric acid methyl ester

There total 2 articles about 3-(4-Hydroxy-2,3,5-trimethyl-phenylsulfanyl)-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

methyl crotonate (623-43-8,4358-59-2,18707-60-3,130981-57-6) + 2,3,5-trimethyl-4-hydroxy-benzenethiol (85460-73-7) → 3-(4-Hydroxy-2,3,5-trimethyl-phenylsulfanyl)-butyric acid methyl ester (101836-22-0)

Guidance literature:

With sulfuric acid; trimethyl orthoformate; In methanol; for 72h; Heating;

DOI:10.1021/jo00360a013

Reference yield:

2,3,5-trimethyl-4-hydroxyphenyl thiocyanate (101836-20-8) → 3-(4-Hydroxy-2,3,5-trimethyl-phenylsulfanyl)-butyric acid methyl ester (101836-22-0)

Guidance literature:

Multi-step reaction with 2 steps

1: LiAlH₄ / diethyl ether; tetrahydrofuran / 1 h / 20 °C

2: 52 percent / trimethyl orthoformate, conc. H₂SO₄ / methanol / 72 h / Heating

With lithium aluminium tetrahydride; sulfuric acid; trimethyl orthoformate; In tetrahydrofuran; methanol; diethyl ether;

DOI:10.1021/jo00360a013

Reference yield: 72.0%

3-(4-Hydroxy-2,3,5-trimethyl-phenylsulfanyl)-butyric acid methyl ester (101836-22-0) → 3-(4-Hydroxy-2,3,5-trimethyl-phenylsulfanyl)-butyric acid (101836-25-3)

Guidance literature:

With sodium hydroxide; In methanol; for 1h; Ambient temperature;

DOI:10.1021/jo00360a013

upstream raw materials:

methyl crotonate

2,3,5-trimethyl-4-hydroxy-benzenethiol

2,3,5-trimethyl-4-hydroxyphenyl thiocyanate

Downstream raw materials:

3-(4-Hydroxy-2,3,5-trimethyl-phenylsulfanyl)-butyric acid