(3R,4S)-3-<3-<3-<(7-nitro-2,1,3-benzoxadiazol-4-yl)amino>propyl>-4-hydroxyphenyl>-4-(4-hydroxyphenyl)hexane

Base Information

Chemical Name:(3R*,4S*)-3-<3-<3-<(7-nitro-2,1,3-benzoxadiazol-4-yl)amino>propyl>-4-hydroxyphenyl>-4-(4-hydroxyphenyl)hexane
CAS No.:104946-90-9
Molecular Formula:C₂₇H₃₀N₄O₅
Molecular Weight:490.559
Hs Code.:

Synonyms:(3R*,4S*)-3-<3-<3-<(7-nitro-2,1,3-benzoxadiazol-4-yl)amino>propyl>-4-hydroxyphenyl>-4-(4-hydroxyphenyl)hexane

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Chemical Property of (3R*,4S*)-3-<3-<3-<(7-nitro-2,1,3-benzoxadiazol-4-yl)amino>propyl>-4-hydroxyphenyl>-4-(4-hydroxyphenyl)hexane

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Technology Process of (3R*,4S*)-3-<3-<3-<(7-nitro-2,1,3-benzoxadiazol-4-yl)amino>propyl>-4-hydroxyphenyl>-4-(4-hydroxyphenyl)hexane

There total 5 articles about (3R*,4S*)-3-<3-<3-<(7-nitro-2,1,3-benzoxadiazol-4-yl)amino>propyl>-4-hydroxyphenyl>-4-(4-hydroxyphenyl)hexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 104946-89-6
{3-[5-{(1R,2S)-1-Ethyl-2-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-butyl}-2-(tetrahydro-pyran-2-yloxy)-phenyl]-propyl}-(7-nitro-benzo[1,2,5]oxadiazol-4-yl)-amine

: 104946-90-9
(3R*,4S*)-3-<3-<3-<(7-nitro-2,1,3-benzoxadiazol-4-yl)amino>propyl>-4-hydroxyphenyl>-4-(4-hydroxyphenyl)hexane

Guidance literature:: With toluene-4-sulfonic acid;
DOI:10.1021/jm00384a026

Reference yield:

: 104946-86-3
(3R*,4S*)-3-<3-(3-aminopropyl)-4-(2-tetrahydropyranyloxy)phenyl>-4-<4-(2-tetrahydropyranyloxy)phenyl>hexane

: 104946-90-9
(3R*,4S*)-3-<3-<3-<(7-nitro-2,1,3-benzoxadiazol-4-yl)amino>propyl>-4-hydroxyphenyl>-4-(4-hydroxyphenyl)hexane

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / methanol / 4 h / Ambient temperature

2: 90 percent / TsOH

With toluene-4-sulfonic acid; triethylamine; In methanol;
DOI:10.1021/jm00384a026

Reference yield:

: 104946-83-0
3-[5-{(1R,2S)-1-Ethyl-2-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-butyl}-2-(tetrahydro-pyran-2-yloxy)-phenyl]-propan-1-ol

: 104946-90-9
(3R*,4S*)-3-<3-<3-<(7-nitro-2,1,3-benzoxadiazol-4-yl)amino>propyl>-4-hydroxyphenyl>-4-(4-hydroxyphenyl)hexane

Guidance literature:: Multi-step reaction with 5 steps

1: 88 percent / pyridine / 8 h / 0 °C

2: 90 percent / dimethylformamide / 3 h / 70 °C

3: 100 percent / hydrazine hydrate / ethanol / 48 h / 25 °C

4: Et₃N / methanol / 4 h / Ambient temperature

5: 90 percent / TsOH

With pyridine; toluene-4-sulfonic acid; hydrazine hydrate; triethylamine; In methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00384a026