(3S)-1-(4-methoxybenzyl)-[(1R)-(tert-butyldimethylsilyloxy)-ethyl]azetidin-2-one

Base Information

Chemical Name:(3S)-1-(4-methoxybenzyl)-[(1R)-(tert-butyldimethylsilyloxy)-ethyl]azetidin-2-one
CAS No.:135684-35-4
Molecular Formula:C₁₉H₃₁NO₃Si
Molecular Weight:349.546
Hs Code.:

Synonyms:(3S)-1-(4-methoxybenzyl)-[(1R)-(tert-butyldimethylsilyloxy)-ethyl]azetidin-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3S)-1-(4-methoxybenzyl)-[(1R)-(tert-butyldimethylsilyloxy)-ethyl]azetidin-2-one

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Technology Process of (3S)-1-(4-methoxybenzyl)-[(1R)-(tert-butyldimethylsilyloxy)-ethyl]azetidin-2-one

There total 2 articles about (3S)-1-(4-methoxybenzyl)-[(1R)-(tert-butyldimethylsilyloxy)-ethyl]azetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 2746-25-0
p-Methoxybenzyl bromide

: 109323-90-2
(1'R,3S)-3-<1'-<(tert-butyldimethylsilyl)oxy>ethyl>azetidin-2-one

: 135684-35-4
(3S)-1-(4-methoxybenzyl)-[(1R)-(tert-butyldimethylsilyloxy)-ethyl]azetidin-2-one

Guidance literature:: With tetra(n-butyl)ammonium hydrogensulfate; potassium iodide; sodium iodide; potassium hydroxide; In tetrahydrofuran; at 20 ℃;
DOI:10.1021/jm200723m

Reference yield:

: 135684-34-3
ethyl (2S,3R)-3-(t-butyldimethylsilyloxy)-2-(4-methoxybenzylaminomethyl)butanoate

: 2633-66-1
2-mesitylmagnesium bromide

: 135684-35-4
(3S)-1-(4-methoxybenzyl)-[(1R)-(tert-butyldimethylsilyloxy)-ethyl]azetidin-2-one

Guidance literature:: With hydrogenchloride; In tetrahydrofuran;

Reference yield: 99.0%

: 135684-35-4
(3S)-1-(4-methoxybenzyl)-[(1R)-(tert-butyldimethylsilyloxy)-ethyl]azetidin-2-one

: 1335557-90-8
(3S)-1-(4-methoxybenzyl)-[(1R)-hydroxyethyl]azetidin-2-one

Guidance literature:: (3S)-1-(4-methoxybenzyl)-[(1R)-(tert-butyldimethylsilyloxy)-ethyl]azetidin-2-one; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 1h;

With acetic acid; In tetrahydrofuran; for 0.25h;
DOI:10.1021/jm200723m