1335557-90-8Relevant articles and documents
SAR and LC/MS studies of β-lactamic inhibitors of human fatty acid amide hydrolase (h FAAH): Evidence of a nonhydrolytic process
Feledziak, Marion,Muccioli, Giulio G.,Lambert, Didier M.,Marchand-Brynaert, Jacqueline
, p. 6812 - 6823 (2011/12/04)
The endocannabinoid hydrolyzing enzyme FAAH uses a nonclassical catalytic triad (namely, Ser-Ser-Lys instead of Ser-Asp-His) to cleave its endogenous substrates. Because inhibiting FAAH has a clear therapeutic potential, we previously developed β-lactam-t