(S)-3-(benzyloxycarbonylamino)-2-(tert-butoxycarbonylamino)propyl methanesulfonate

Base Information

Chemical Name:(S)-3-(benzyloxycarbonylamino)-2-(tert-butoxycarbonylamino)propyl methanesulfonate
CAS No.:1269759-88-7
Molecular Formula:C₁₇H₂₆N₂O₇S
Molecular Weight:402.469
Hs Code.:

Synonyms:(S)-3-(benzyloxycarbonylamino)-2-(tert-butoxycarbonylamino)propyl methanesulfonate

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Chemical Property of (S)-3-(benzyloxycarbonylamino)-2-(tert-butoxycarbonylamino)propyl methanesulfonate

Chemical Property:

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Technology Process of (S)-3-(benzyloxycarbonylamino)-2-(tert-butoxycarbonylamino)propyl methanesulfonate

There total 5 articles about (S)-3-(benzyloxycarbonylamino)-2-(tert-butoxycarbonylamino)propyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1429913-70-1,1263045-28-8
benzyl tert-butyl (3-hydroxypropane-1,2-diyl)biscarbamate

: 124-63-0
methanesulfonyl chloride

: 1269759-88-7
(S)-3-(benzyloxycarbonylamino)-2-(tert-butoxycarbonylamino)propyl methanesulfonate

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 2h;

Reference yield:

: 721927-81-7,1263045-28-8
benzyl tert-butyl [(2S)-3-hydroxypropan-1,2-diyl]biscarbamate

: 124-63-0
methanesulfonyl chloride

: 1269759-88-7
(S)-3-(benzyloxycarbonylamino)-2-(tert-butoxycarbonylamino)propyl methanesulfonate

Guidance literature:: benzyl tert-butyl [(2S)-3-hydroxypropan-1,2-diyl]biscarbamate; With triethylamine; In dichloromethane; at 0 ℃; for 0.166667h; Inert atmosphere;

methanesulfonyl chloride; In dichloromethane; for 0.666667h; Cooling with ice; Inert atmosphere;
DOI:10.1039/c0cc03988h

Reference yield:

: 65710-57-8,81306-93-6
3-{[(benzyloxy)carbonyl]amino}-N-(tert-butoxycarbonyl)-L-alanine

: 1269759-88-7
(S)-3-(benzyloxycarbonylamino)-2-(tert-butoxycarbonylamino)propyl methanesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 8.25 h / 20 °C / Cooling with ice

2.1: sodium tetrahydroborate; lithium bromide / tetrahydrofuran; ethanol / 20 °C / Inert atmosphere; Cooling with ice

3.1: triethylamine / dichloromethane / 0.17 h / 0 °C / Inert atmosphere

3.2: 0.67 h / Cooling with ice; Inert atmosphere

With sodium tetrahydroborate; potassium carbonate; triethylamine; lithium bromide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c0cc03988h