Technology Process of N-((1-benzyl-1H-imidazol-5-yl)methyl)-N-ethylethanamine
There total 4 articles about N-((1-benzyl-1H-imidazol-5-yl)methyl)-N-ethylethanamine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1-benzyl-1H-imidazole-5-carboxaldehyde; diethylamine;
With
titanium tetra-n-propoxide;
In
dichloromethane;
at 20 ℃;
for 4h;
Inert atmosphere;
With
sodium cyanoborohydride;
In
ethanol; dichloromethane;
at 20 ℃;
for 16h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: hydrogenchloride / water; acetonitrile / 0.05 h / Cooling with ice
1.2: 2 h / 70 °C
2.1: acetic acid; dihydrogen peroxide / water; dichloromethane / 0.5 h / 20 °C / Reflux
3.1: manganese(IV) oxide / 1,4-dioxane / 3 h / 60 °C
4.1: titanium tetra-n-propoxide / dichloromethane / 4 h / 20 °C / Inert atmosphere
4.2: 16 h / 20 °C
With
hydrogenchloride; manganese(IV) oxide; titanium tetra-n-propoxide; dihydrogen peroxide; acetic acid;
In
1,4-dioxane; dichloromethane; water; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: acetic acid; dihydrogen peroxide / water; dichloromethane / 0.5 h / 20 °C / Reflux
2.1: manganese(IV) oxide / 1,4-dioxane / 3 h / 60 °C
3.1: titanium tetra-n-propoxide / dichloromethane / 4 h / 20 °C / Inert atmosphere
3.2: 16 h / 20 °C
With
manganese(IV) oxide; titanium tetra-n-propoxide; dihydrogen peroxide; acetic acid;
In
1,4-dioxane; dichloromethane; water;
