2-[6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl]acetonitrile

Base Information

• Chemical Name: 2-[6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl]acetonitrile
• CAS No.: 1061179-18-7
• Molecular Formula: C₂₃H₂₁ClN₂
• Molecular Weight: 360.886
• Mol file: 1061179-18-7.mol

Synonyms:2-[6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl]acetonitrile

Chemical Property of 2-[6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl]acetonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl]acetonitrile

There total 2 articles about 2-[6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl]acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

iodoacetonitrile (624-75-9) + 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine (133111-56-5) → 2-[6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl]acetonitrile (1061179-18-7)

Guidance literature:

With dihydrogen peroxide; iron(II) sulfate; In dimethyl sulfoxide; for 4.5h;

DOI:10.1016/j.tetlet.2008.06.078

Reference yield:

sodium cyanide (773837-37-9) + C24H27ClN2 (1175530-67-2) → 2-[6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl]acetonitrile (1061179-18-7)

Guidance literature:

With methyl iodide;

DOI:10.1021/jm900481c

Reference yield: 48.0%

2-[6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl]acetonitrile (1061179-18-7) → 2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl)acetamide (1061179-22-3)

Guidance literature:

2-[6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl]acetonitrile; With sodium hydroxide; water; In ethanol; for 2h; Heating / reflux;

With hydrogenchloride; In ethanol; water;

upstream raw materials:

iodoacetonitrile

6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine

sodium cyanide

C₂₄H₂₇ClN₂

Downstream raw materials:

2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl)acetamide

C₂₃H₂₂ClN₅