2,3-bis(3-methoxyphenyl)-1-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)propan-1-one

Base Information

• Chemical Name: 2,3-bis(3-methoxyphenyl)-1-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)propan-1-one
• CAS No.: 1352547-09-1
• Molecular Formula: C₃₁H₃₇NO₄
• Molecular Weight: 487.639
• Mol file: 1352547-09-1.mol

Synonyms:2,3-bis(3-methoxyphenyl)-1-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)propan-1-one

Chemical Property of 2,3-bis(3-methoxyphenyl)-1-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)propan-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,3-bis(3-methoxyphenyl)-1-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)propan-1-one

There total 4 articles about 2,3-bis(3-methoxyphenyl)-1-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(4-iodophenyl)-2,3-bis(3-methoxyphenyl)propan-1-one (1352547-02-4) + (S)-2-((R)-3-methylpyrrolidin-1-yl)propan-1-ol (620627-27-2) → 2,3-bis(3-methoxyphenyl)-1-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)propan-1-one (1352547-09-1)

Guidance literature:

With potassium carbonate; [2,2]bipyridinyl; copper(l) iodide; In diethylene glycol dimethyl ether; m-xylene; at 140 ℃; for 31h; Inert atmosphere;

Reference yield:

(R)-methylsuccinic acid dimethyl ester (22644-27-5) → 2,3-bis(3-methoxyphenyl)-1-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)propan-1-one (1352547-09-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 17 h / 0 - 20 °C / Inert atmosphere

1.2: 3 h / 20 °C

2.1: triethylamine / dichloromethane / 1.5 h / -20 - -15 °C

3.1: 24 h / 20 °C / Neat (no solvent)

4.1: potassium carbonate / [2,2]bipyridinyl; copper(l) iodide / m-xylene; diethylene glycol dimethyl ether / 31 h / 140 °C / Inert atmosphere

With lithium aluminium tetrahydride; potassium carbonate; triethylamine; [2,2]bipyridinyl; copper(l) iodide; In tetrahydrofuran; dichloromethane; diethylene glycol dimethyl ether; m-xylene; 4.1: Ullmann Condensation;

Reference yield:

(+)-(R)-2-methylbutane-1,4-diyl dimethanesulfonate → 2,3-bis(3-methoxyphenyl)-1-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)propan-1-one (1352547-09-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 24 h / 20 °C / Neat (no solvent)

2: potassium carbonate / [2,2]bipyridinyl; copper(l) iodide / m-xylene; diethylene glycol dimethyl ether / 31 h / 140 °C / Inert atmosphere

With potassium carbonate; [2,2]bipyridinyl; copper(l) iodide; In diethylene glycol dimethyl ether; m-xylene; 2: Ullmann Condensation;

upstream raw materials:

(R)-methylsuccinic acid dimethyl ester

1-(4-iodophenyl)-2,3-bis(3-methoxyphenyl)propan-1-one

(S)-2-((R)-3-methylpyrrolidin-1-yl)propan-1-ol

(R)-2-methylbutane-1,4-diol

Downstream raw materials:

(R)-1-((S)-1-(4-(6-methoxy-2-(3-methoxyphenyl)-1H-inden-3-yl)phenoxy)propan-2-yl)-3-methylpyrrolidine