2,3-bis(3-methoxyphenyl)-1-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)propan-1-one

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Chemical Name:2,3-bis(3-methoxyphenyl)-1-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)propan-1-one
CAS No.:1352547-09-1
Molecular Formula:C₃₁H₃₇NO₄
Molecular Weight:487.639
Hs Code.:

Synonyms:2,3-bis(3-methoxyphenyl)-1-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)propan-1-one

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Chemical Property of 2,3-bis(3-methoxyphenyl)-1-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)propan-1-one

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Technology Process of 2,3-bis(3-methoxyphenyl)-1-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)propan-1-one

There total 4 articles about 2,3-bis(3-methoxyphenyl)-1-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1352547-02-4
1-(4-iodophenyl)-2,3-bis(3-methoxyphenyl)propan-1-one

: 620627-27-2
(S)-2-((R)-3-methylpyrrolidin-1-yl)propan-1-ol

: 1352547-09-1
2,3-bis(3-methoxyphenyl)-1-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)propan-1-one

Guidance literature:: With potassium carbonate; [2,2]bipyridinyl; copper(l) iodide; In diethylene glycol dimethyl ether; m-xylene; at 140 ℃; for 31h; Inert atmosphere;

Reference yield:

: 22644-27-5
(R)-methylsuccinic acid dimethyl ester

: 1352547-09-1
2,3-bis(3-methoxyphenyl)-1-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)propan-1-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 17 h / 0 - 20 °C / Inert atmosphere

1.2: 3 h / 20 °C

2.1: triethylamine / dichloromethane / 1.5 h / -20 - -15 °C

3.1: 24 h / 20 °C / Neat (no solvent)

4.1: potassium carbonate / [2,2]bipyridinyl; copper(l) iodide / m-xylene; diethylene glycol dimethyl ether / 31 h / 140 °C / Inert atmosphere

With lithium aluminium tetrahydride; potassium carbonate; triethylamine; [2,2]bipyridinyl; copper(l) iodide; In tetrahydrofuran; dichloromethane; diethylene glycol dimethyl ether; m-xylene; 4.1: Ullmann Condensation;

Reference yield:

: (+)-(R)-2-methylbutane-1,4-diyl dimethanesulfonate

: 1352547-09-1
2,3-bis(3-methoxyphenyl)-1-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)propan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: 24 h / 20 °C / Neat (no solvent)

2: potassium carbonate / [2,2]bipyridinyl; copper(l) iodide / m-xylene; diethylene glycol dimethyl ether / 31 h / 140 °C / Inert atmosphere

With potassium carbonate; [2,2]bipyridinyl; copper(l) iodide; In diethylene glycol dimethyl ether; m-xylene; 2: Ullmann Condensation;