(R)-1-((S)-1-(4-(6-methoxy-2-(3-methoxyphenyl)-1H-inden-3-yl)phenoxy)propan-2-yl)-3-methylpyrrolidine

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Chemical Name:(R)-1-((S)-1-(4-(6-methoxy-2-(3-methoxyphenyl)-1H-inden-3-yl)phenoxy)propan-2-yl)-3-methylpyrrolidine
CAS No.:1352547-10-4
Molecular Formula:C₃₁H₃₅NO₃
Molecular Weight:469.624
Hs Code.:

Synonyms:(R)-1-((S)-1-(4-(6-methoxy-2-(3-methoxyphenyl)-1H-inden-3-yl)phenoxy)propan-2-yl)-3-methylpyrrolidine

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Chemical Property of (R)-1-((S)-1-(4-(6-methoxy-2-(3-methoxyphenyl)-1H-inden-3-yl)phenoxy)propan-2-yl)-3-methylpyrrolidine

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Technology Process of (R)-1-((S)-1-(4-(6-methoxy-2-(3-methoxyphenyl)-1H-inden-3-yl)phenoxy)propan-2-yl)-3-methylpyrrolidine

There total 4 articles about (R)-1-((S)-1-(4-(6-methoxy-2-(3-methoxyphenyl)-1H-inden-3-yl)phenoxy)propan-2-yl)-3-methylpyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1352547-09-1
2,3-bis(3-methoxyphenyl)-1-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)propan-1-one

: 1352547-10-4
(R)-1-((S)-1-(4-(6-methoxy-2-(3-methoxyphenyl)-1H-inden-3-yl)phenoxy)propan-2-yl)-3-methylpyrrolidine

Guidance literature:: 2,3-bis(3-methoxyphenyl)-1-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)propan-1-one; With methanesulfonic acid; In dichloromethane; at 20 ℃; for 20h;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield:

: 22644-27-5
(R)-methylsuccinic acid dimethyl ester

: 1352547-10-4
(R)-1-((S)-1-(4-(6-methoxy-2-(3-methoxyphenyl)-1H-inden-3-yl)phenoxy)propan-2-yl)-3-methylpyrrolidine

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 17 h / 0 - 20 °C / Inert atmosphere

1.2: 3 h / 20 °C

2.1: triethylamine / dichloromethane / 1.5 h / -20 - -15 °C

3.1: 24 h / 20 °C / Neat (no solvent)

4.1: potassium carbonate / [2,2]bipyridinyl; copper(l) iodide / m-xylene; diethylene glycol dimethyl ether / 31 h / 140 °C / Inert atmosphere

5.1: methanesulfonic acid / dichloromethane / 20 h / 20 °C

With lithium aluminium tetrahydride; methanesulfonic acid; potassium carbonate; triethylamine; [2,2]bipyridinyl; copper(l) iodide; In tetrahydrofuran; dichloromethane; diethylene glycol dimethyl ether; m-xylene; 4.1: Ullmann Condensation;

Reference yield:

: (+)-(R)-2-methylbutane-1,4-diyl dimethanesulfonate

: 1352547-10-4
(R)-1-((S)-1-(4-(6-methoxy-2-(3-methoxyphenyl)-1H-inden-3-yl)phenoxy)propan-2-yl)-3-methylpyrrolidine

Guidance literature:: Multi-step reaction with 3 steps

1: 24 h / 20 °C / Neat (no solvent)

2: potassium carbonate / [2,2]bipyridinyl; copper(l) iodide / m-xylene; diethylene glycol dimethyl ether / 31 h / 140 °C / Inert atmosphere

3: methanesulfonic acid / dichloromethane / 20 h / 20 °C

With methanesulfonic acid; potassium carbonate; [2,2]bipyridinyl; copper(l) iodide; In dichloromethane; diethylene glycol dimethyl ether; m-xylene; 2: Ullmann Condensation;