2-(3-fluoro-phenyl)-4-methylpyrimidine-5-carboxylic acid (3-dimethylsulfamoyl-5-fluoro-indol-1-yl)amide

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Chemical Name:2-(3-fluoro-phenyl)-4-methylpyrimidine-5-carboxylic acid (3-dimethylsulfamoyl-5-fluoro-indol-1-yl)amide
CAS No.:1068968-25-1
Molecular Formula:C₂₂H₁₉F₂N₅O₃S
Molecular Weight:471.487
Hs Code.:

Synonyms:2-(3-fluoro-phenyl)-4-methylpyrimidine-5-carboxylic acid (3-dimethylsulfamoyl-5-fluoro-indol-1-yl)amide

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Chemical Property of 2-(3-fluoro-phenyl)-4-methylpyrimidine-5-carboxylic acid (3-dimethylsulfamoyl-5-fluoro-indol-1-yl)amide

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Technology Process of 2-(3-fluoro-phenyl)-4-methylpyrimidine-5-carboxylic acid (3-dimethylsulfamoyl-5-fluoro-indol-1-yl)amide

There total 9 articles about 2-(3-fluoro-phenyl)-4-methylpyrimidine-5-carboxylic acid (3-dimethylsulfamoyl-5-fluoro-indol-1-yl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 933989-07-2
2-(3-fluoro-phenyl)-4-methyl-pyrimidine-5-carboxylic acid

: 1068975-07-4
1-amino-5-fluoro-1H-indole-3-sulfonic acid dimethylamide

: 1068968-25-1
2-(3-fluoro-phenyl)-4-methylpyrimidine-5-carboxylic acid (3-dimethylsulfamoyl-5-fluoro-indol-1-yl)amide

Guidance literature:: 2-(3-fluoro-phenyl)-4-methyl-pyrimidine-5-carboxylic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.666667h;

1-amino-5-fluoro-1H-indole-3-sulfonic acid dimethylamide; In N,N-dimethyl-formamide; at 80 ℃; for 24h;

Reference yield:

: 399-52-0
5-fluoro-1H-indole

: 1068968-25-1
2-(3-fluoro-phenyl)-4-methylpyrimidine-5-carboxylic acid (3-dimethylsulfamoyl-5-fluoro-indol-1-yl)amide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide / tetra(n-butyl)ammonium hydrogensulfate / water; toluene / 24 h / 20 °C

2.1: chlorosulfonic acid / acetonitrile / 24 h / 0 - 20 °C

3.1: dichloromethane; water / 20 h / 20 °C

4.1: methanol; potassium hydroxide; water / 1.5 h / Heating / reflux

4.2: pH ~ 3

5.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

5.2: 5 h / 0 - 20 °C

5.3: 0 °C

6.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.67 h / 20 °C

6.2: 24 h / 80 °C

With methanol; chlorosulfonic acid; potassium hydroxide; sodium hydroxide; water; sodium hydride; N-ethyl-N,N-diisopropylamine; HATU; tetra(n-butyl)ammonium hydrogensulfate; In dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 719308-89-1
5-fluoro-1-[(4-methylphenyl)sulfonyl]-1H-indole

: 1068968-25-1
2-(3-fluoro-phenyl)-4-methylpyrimidine-5-carboxylic acid (3-dimethylsulfamoyl-5-fluoro-indol-1-yl)amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: chlorosulfonic acid / acetonitrile / 24 h / 0 - 20 °C

2.1: dichloromethane; water / 20 h / 20 °C

3.1: methanol; potassium hydroxide; water / 1.5 h / Heating / reflux

3.2: pH ~ 3

4.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

4.2: 5 h / 0 - 20 °C

4.3: 0 °C

5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.67 h / 20 °C

5.2: 24 h / 80 °C

With methanol; chlorosulfonic acid; potassium hydroxide; water; sodium hydride; N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;