Tiletamine hydrochloride

Base Information

• Chemical Name: Tiletamine hydrochloride
• CAS No.: 14176-50-2
• Molecular Formula: C₁₂H₁₇NOS*ClH
• Molecular Weight: 259.8
• Hs Code.: 2934990002
• European Community (EC) Number: 604-248-6
• NSC Number: 760368,167740
• UNII: 99TAQ2QWJI
• DSSTox Substance ID: DTXSID6045539
• Wikidata: Q27272243
• NCI Thesaurus Code: C84212
• ChEMBL ID: CHEMBL2105342
• Mol file: 14176-50-2.mol

Synonyms:2-(Ethylamino)-2-(2-thienyl)cyclohexanone;CI 634;CI-634;CI634;Hydrochloride, Tiletamine;Tiletamine;Tiletamine Hydrochloride

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Chemical Property of Tiletamine hydrochloride

Chemical Property:

• Appearance/Colour: white powder
• Vapor Pressure: 3.79E-05mmHg at 25°C
• Boiling Point: 352.6 °C at 760 mmHg
• Flash Point: 167.1 °C
• PSA: 57.34000
• LogP: 3.88890
• Storage Temp.: Refrigerator, Under Inert Atmosphere
• Solubility.: DMSO (Slightly, Heated), Methanol (Slightly)
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 259.0797631
• Heavy Atom Count: 16
• Complexity: 244

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCNC1(CCCCC1=O)C2=CC=CS2.Cl
• Uses: Tiletamine is a receptor antagonist, an anesthetic drug. Tiletamine is related chemically and pharmacologically to other anesthetics in this family such as ketamine and phencyclidine.
• Indications: Tiletamine hydrochloride/zolazepam hydrochloride is used for chemical immobilization and surgical anesthesia in a wide variety of carnivores, artiodactylids, birds, reptiles, and amphibians.

Technology Process of Tiletamine hydrochloride

There total 4 articles about Tiletamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Tiletamine (14176-49-9) → CI-634 (14176-50-2)

Guidance literature:

With hydrogenchloride; In diethyl ether; water; at 0 ℃; for 2h; Inert atmosphere;

DOI:10.1055/s-0035-1561294

Reference yield: 70.0%

→ CI-634 (14176-50-2)

Guidance literature:

Reference yield:

(1R*,2S*)-2-amino-2-(2-thienyl)cyclohexanol → CI-634 (14176-50-2)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium cyanoborohydride; acetic acid / methanol / 1.5 h / 0 - 20 °C / Inert atmosphere

2: Jones reagent / acetone / 0.5 h / 20 °C / Inert atmosphere

3: hydrogenchloride / water; diethyl ether / 2 h / 0 °C / Inert atmosphere

With hydrogenchloride; Jones reagent; sodium cyanoborohydride; acetic acid; In methanol; diethyl ether; water; acetone;

DOI:10.1055/s-0035-1561294

upstream raw materials:

Tiletamine

Refernces

• 1、 -. "Synthesis of cyclopentyl 2-thienyl ketone, tiletamine and tiletamine acid addition salts, such as tiletamine hydrochloride". . . Retrieved 2008/06/13.