N-{4-(2,6-dimethyl-4-(pyrimidin-2-yloxy)phenyl)thiazol-2-yl}isonicotinamide

Base Information

Chemical Name:N-{4-(2,6-dimethyl-4-(pyrimidin-2-yloxy)phenyl)thiazol-2-yl}isonicotinamide
CAS No.:1439935-98-4
Molecular Formula:C₂₁H₁₇N₅O₂S
Molecular Weight:403.464
Hs Code.:

Synonyms:N-{4-(2,6-dimethyl-4-(pyrimidin-2-yloxy)phenyl)thiazol-2-yl}isonicotinamide

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Chemical Property of N-{4-(2,6-dimethyl-4-(pyrimidin-2-yloxy)phenyl)thiazol-2-yl}isonicotinamide

Chemical Property:

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Technology Process of N-{4-(2,6-dimethyl-4-(pyrimidin-2-yloxy)phenyl)thiazol-2-yl}isonicotinamide

There total 4 articles about N-{4-(2,6-dimethyl-4-(pyrimidin-2-yloxy)phenyl)thiazol-2-yl}isonicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 1439936-01-2
4-(2,6-dimethyl-4-(pyrimidin-2-yloxy)phenyl)thiazol-2-amine

: 39178-35-3
isonicotinoyl chloride hydrochloride

: 1439935-98-4
N-{4-(2,6-dimethyl-4-(pyrimidin-2-yloxy)phenyl)thiazol-2-yl}isonicotinamide

Guidance literature:: With triethylamine; In tetrahydrofuran; at 60 ℃;

Reference yield:

: 91060-92-3
1-(4-hydroxy-2,6-dimethylphenyl)ethanone

: 1439935-98-4
N-{4-(2,6-dimethyl-4-(pyrimidin-2-yloxy)phenyl)thiazol-2-yl}isonicotinamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate; copper / N,N-dimethyl-formamide / 3 h / 100 °C

2: tetrabutylammomium bromide / acetonitrile / 20 °C

3: ethanol / 1 h / Reflux

4: triethylamine / tetrahydrofuran / 60 °C

With tetrabutylammomium bromide; copper; potassium carbonate; triethylamine; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1439935-99-5
1-(2,6-dimethyl-4-(pyrimidin-2-yloxy)phenyl)ethanone

: 1439935-98-4
N-{4-(2,6-dimethyl-4-(pyrimidin-2-yloxy)phenyl)thiazol-2-yl}isonicotinamide

Guidance literature:: Multi-step reaction with 3 steps

1: tetrabutylammomium bromide / acetonitrile / 20 °C

2: ethanol / 1 h / Reflux

3: triethylamine / tetrahydrofuran / 60 °C

With tetrabutylammomium bromide; triethylamine; In tetrahydrofuran; ethanol; acetonitrile;