1H-1,3-BENZIMIDAZOL-2-YLMETHYL PHENYL SULFIDE

Base Information

• Chemical Name: 1H-1,3-BENZIMIDAZOL-2-YLMETHYL PHENYL SULFIDE
• CAS No.: 3176-72-5
• Molecular Formula: C₁₄H₁₂N₂S
• Molecular Weight: 240.329
• Mol file: 3176-72-5.mol

Synonyms:2-((phenylsulfanyl)methyl)-1H-benzimidazole

Chemical Property of 1H-1,3-BENZIMIDAZOL-2-YLMETHYL PHENYL SULFIDE

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

1H-1,3-BENZIMIDAZOL-2-YLMETHYL PHENYL SULFIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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Technology Process of 1H-1,3-BENZIMIDAZOL-2-YLMETHYL PHENYL SULFIDE

There total 7 articles about 1H-1,3-BENZIMIDAZOL-2-YLMETHYL PHENYL SULFIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-chloromethyl-1H-benzimidazole (4857-04-9) + thiophenol (108-98-5) → 2-((phenylsulfanyl)methyl)-1H-benzimidazole (3176-72-5)

Guidance literature:

thiophenol; With potassium carbonate; for 2h; Reflux;

2-chloromethyl-1H-benzimidazole; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

DOI:10.1016/j.bmcl.2012.03.061

Reference yield: 92.0%

(phenylthio)acetic acid (103-04-8) + 1,2-diamino-benzene (95-54-5) → 2-((phenylsulfanyl)methyl)-1H-benzimidazole (3176-72-5)

Guidance literature:

With boric acid; In toluene; for 10h; Reflux;

DOI:10.1002/hlca.201100064

Reference yield: 71.0%

thiophenol (108-98-5) + 2-trichloromethyl-1H-benzoimidazole (3584-65-4) → 2-((phenylsulfanyl)methyl)-1H-benzimidazole (3176-72-5)

Guidance literature:

With sodium hydride; In tetrahydrofuran; 1.) r.t., 10 min, 2.) r.t., 5 min;

DOI:10.1055/s-1999-3376

upstream raw materials:

2-chloromethyl-1H-benzimidazole

thiophenol

2-trichloromethyl-1H-benzoimidazole

(phenylthio)acetic acid

Downstream raw materials:

1-isobutyl-2-[(phenylthio)methyl]-1H-benzimidazole

N'-(3-hydroxy-4-methoxybenzylidene)-2-(2-(phenylthiomethyl)-1H-benzo[d]imidazol-1-yl)acetohydrazide

N'-(3-hydroxy-4-methoxybenzylidene)-2-(2-(phenylthiomethyl)-1H-benzo[d]imidazol-1-yl)acetohydrazide

N'-(4-methoxybenzylidene)-2-(2-(phenylthiomethyl)-1H-benzo[d]imidazol-1-yl)acetohydrazide

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