N'-(2,4-dihydroxybenzylidene)-2-(2-(phenylthiomethyl)-1H-benzo[d]imidazol-1-yl)acetohydrazide

Base Information

• Chemical Name: N'-(2,4-dihydroxybenzylidene)-2-(2-(phenylthiomethyl)-1H-benzo[d]imidazol-1-yl)acetohydrazide
• CAS No.: 1374511-02-0
• Molecular Formula: C₂₃H₂₀N₄O₃S
• Molecular Weight: 432.503
• Mol file: 1374511-02-0.mol

Synonyms:N'-(2,4-dihydroxybenzylidene)-2-(2-(phenylthiomethyl)-1H-benzo[d]imidazol-1-yl)acetohydrazide

Chemical Property of N'-(2,4-dihydroxybenzylidene)-2-(2-(phenylthiomethyl)-1H-benzo[d]imidazol-1-yl)acetohydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N'-(2,4-dihydroxybenzylidene)-2-(2-(phenylthiomethyl)-1H-benzo[d]imidazol-1-yl)acetohydrazide

There total 5 articles about N'-(2,4-dihydroxybenzylidene)-2-(2-(phenylthiomethyl)-1H-benzo[d]imidazol-1-yl)acetohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C16H16N4OS (1374511-01-9) + 2,4-Dihydroxybenzaldehyde (95-01-2) → N'-(2,4-dihydroxybenzylidene)-2-(2-(phenylthiomethyl)-1H-benzo[d]imidazol-1-yl)acetohydrazide (1374511-02-0) + N'-(2,4-dihydroxybenzylidene)-2-(2-(phenylthiomethyl)-1H-benzo[d]imidazol-1-yl)acetohydrazide (1374511-26-8)

Guidance literature:

With acetic acid; In ethanol; at 90 ℃; for 2h; optical yield given as %de;

DOI:10.1016/j.bmcl.2012.03.061

Reference yield:

2-chloromethyl-1H-benzimidazole (4857-04-9) → N'-(2,4-dihydroxybenzylidene)-2-(2-(phenylthiomethyl)-1H-benzo[d]imidazol-1-yl)acetohydrazide (1374511-02-0) + N'-(2,4-dihydroxybenzylidene)-2-(2-(phenylthiomethyl)-1H-benzo[d]imidazol-1-yl)acetohydrazide (1374511-26-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: potassium carbonate / 2 h / Reflux

1.2: 0.5 h / 20 °C

2.1: potassium carbonate / acetone / 6 h / 20 °C

3.1: hydrazine hydrate / ethanol / 7 h / 20 °C

4.1: acetic acid / ethanol / 2 h / 90 °C

With potassium carbonate; hydrazine hydrate; acetic acid; In ethanol; acetone;

DOI:10.1016/j.bmcl.2012.03.061

Reference yield:

tert-butyl 2-(2-(phenylthiomethyl)-1H-benzo[d]imidazol-1-yl)acetate (1374511-00-8) → N'-(2,4-dihydroxybenzylidene)-2-(2-(phenylthiomethyl)-1H-benzo[d]imidazol-1-yl)acetohydrazide (1374511-02-0) + N'-(2,4-dihydroxybenzylidene)-2-(2-(phenylthiomethyl)-1H-benzo[d]imidazol-1-yl)acetohydrazide (1374511-26-8)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / 7 h / 20 °C

2: acetic acid / ethanol / 2 h / 90 °C

With hydrazine hydrate; acetic acid; In ethanol;

DOI:10.1016/j.bmcl.2012.03.061

upstream raw materials:

2-chloromethyl-1H-benzimidazole

tert-butyl 2-(2-(phenylthiomethyl)-1H-benzo[d]imidazol-1-yl)acetate

C₁₆H₁₆N₄OS

2,4-Dihydroxybenzaldehyde