2-acetylamino-2-{3-[2-nitro-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-propyl}-malonic acid

Base Information

Chemical Name:2-acetylamino-2-{3-[2-nitro-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-propyl}-malonic acid
CAS No.:338735-76-5
Molecular Formula:C₁₆H₁₅F₃N₄O₇
Molecular Weight:432.313
Hs Code.:

2-acetylamino-2-{3-[2-nitro-4-(3-trifluoromethyl-3<i>H</i>-diazirin-3-yl)-phenyl]-propyl}-malonic acid

Synonyms:2-acetylamino-2-{3-[2-nitro-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-propyl}-malonic acid

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Chemical Property of 2-acetylamino-2-{3-[2-nitro-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-propyl}-malonic acid

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Technology Process of 2-acetylamino-2-{3-[2-nitro-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-propyl}-malonic acid

There total 3 articles about 2-acetylamino-2-{3-[2-nitro-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-propyl}-malonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 338735-74-3
diethyl acetamido[3-[4-(1-azi-2,2,2-trifluoroethyl)-2-nitrophenyl]propyl]malonate

: 338735-76-5
2-acetylamino-2-{3-[2-nitro-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-propyl}-malonic acid

Guidance literature:: With sodium hydroxide; In ethanol; water; at 20 ℃;
DOI:10.3987/com-00-s(i)90

Reference yield:

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

: 338735-76-5
2-acetylamino-2-{3-[2-nitro-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-propyl}-malonic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 53 percent / NaH / dimethylformamide / 24 h / 20 °C

2: 100 percent / aq. NaOH / ethanol; H₂O / 20 °C

With sodium hydroxide; sodium hydride; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.3987/com-00-s(i)90

Reference yield:

: 271252-22-3
3-(azi-2,2,2-trifluoroethyl)-6-(3-bromopropyl)-1-nitrobenzene

: 338735-76-5
2-acetylamino-2-{3-[2-nitro-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-propyl}-malonic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 53 percent / NaH / dimethylformamide / 24 h / 20 °C

2: 100 percent / aq. NaOH / ethanol; H₂O / 20 °C

With sodium hydroxide; sodium hydride; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.3987/com-00-s(i)90