diethyl acetamido[3-[4-(1-azi-2,2,2-trifluoroethyl)-2-nitrophenyl]propyl]malonate

Base Information

Chemical Name:diethyl acetamido[3-[4-(1-azi-2,2,2-trifluoroethyl)-2-nitrophenyl]propyl]malonate
CAS No.:338735-74-3
Molecular Formula:C₂₀H₂₃F₃N₄O₇
Molecular Weight:488.42
Hs Code.:

Synonyms:diethyl acetamido[3-[4-(1-azi-2,2,2-trifluoroethyl)-2-nitrophenyl]propyl]malonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of diethyl acetamido[3-[4-(1-azi-2,2,2-trifluoroethyl)-2-nitrophenyl]propyl]malonate

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Technology Process of diethyl acetamido[3-[4-(1-azi-2,2,2-trifluoroethyl)-2-nitrophenyl]propyl]malonate

There total 1 articles about diethyl acetamido[3-[4-(1-azi-2,2,2-trifluoroethyl)-2-nitrophenyl]propyl]malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

: 271252-22-3
3-(azi-2,2,2-trifluoroethyl)-6-(3-bromopropyl)-1-nitrobenzene

: 338735-74-3
diethyl acetamido[3-[4-(1-azi-2,2,2-trifluoroethyl)-2-nitrophenyl]propyl]malonate

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 24h;
DOI:10.3987/com-00-s(i)90

Reference yield: 100.0%

: 338735-74-3
diethyl acetamido[3-[4-(1-azi-2,2,2-trifluoroethyl)-2-nitrophenyl]propyl]malonate

: 338735-76-5
2-acetylamino-2-{3-[2-nitro-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-propyl}-malonic acid

Guidance literature:: With sodium hydroxide; In ethanol; water; at 20 ℃;
DOI:10.3987/com-00-s(i)90

Reference yield:

: 338735-74-3
diethyl acetamido[3-[4-(1-azi-2,2,2-trifluoroethyl)-2-nitrophenyl]propyl]malonate

: 2-acetylamino-5-[2-nitro-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-pentanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / aq. NaOH / ethanol; H₂O / 20 °C

2: dioxane / 1 h / 80 °C

3: aq. NaOH; CoCl₂; Aspergillus genus enzyme / aq. phosphate buffer / 48 h / 35 - 38 °C / pH 6.7

With sodium hydroxide; Aspergillus genus enzyme; In 1,4-dioxane; phosphate buffer; ethanol; water;
DOI:10.3987/com-00-s(i)90