5-(6-(4-(4-(dimethylamino)piperidine-1-carbonyl)phenyl)imidazo[1,2-b]pyridazin-3-yl)isoindolin-1-one

Base Information

Chemical Name:5-(6-(4-(4-(dimethylamino)piperidine-1-carbonyl)phenyl)imidazo[1,2-b]pyridazin-3-yl)isoindolin-1-one
CAS No.:1464151-28-7
Molecular Formula:C₂₈H₂₈N₆O₂
Molecular Weight:480.569
Hs Code.:

Synonyms:5-(6-(4-(4-(dimethylamino)piperidine-1-carbonyl)phenyl)imidazo[1,2-b]pyridazin-3-yl)isoindolin-1-one

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Chemical Property of 5-(6-(4-(4-(dimethylamino)piperidine-1-carbonyl)phenyl)imidazo[1,2-b]pyridazin-3-yl)isoindolin-1-one

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Technology Process of 5-(6-(4-(4-(dimethylamino)piperidine-1-carbonyl)phenyl)imidazo[1,2-b]pyridazin-3-yl)isoindolin-1-one

There total 5 articles about 5-(6-(4-(4-(dimethylamino)piperidine-1-carbonyl)phenyl)imidazo[1,2-b]pyridazin-3-yl)isoindolin-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 376584-62-2
5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoindolin-1-one

: 1464154-53-7
(4-(3-bromoimidazo[1,2-b]pyridazin-6-yl)phenyl)(4-(dimethylamino)piperidin-1-yl)methanone

: 1464151-28-7
5-(6-(4-(4-(dimethylamino)piperidine-1-carbonyl)phenyl)imidazo[1,2-b]pyridazin-3-yl)isoindolin-1-one

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; In water; N,N-dimethyl-formamide; at 90 ℃; for 18h;

Reference yield:

: 14047-29-1
4-carboxyphenylboronic acid

: 1464151-28-7
5-(6-(4-(4-(dimethylamino)piperidine-1-carbonyl)phenyl)imidazo[1,2-b]pyridazin-3-yl)isoindolin-1-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium phosphate / water; 1,4-dioxane / 6 h / 20 °C / Inert atmosphere; Reflux

2.1: N-Bromosuccinimide / acetonitrile / 3 h / 0 °C

3.1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.2: 16 h / 20 °C

4.1: caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; N,N-dimethyl-formamide / 18 h / 90 °C

With 4-methyl-morpholine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; HATU; In 1,4-dioxane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1084953-09-2
4-(imidazo[1,2-b]pyridazin-6-yl)benzoic acid

: 1464151-28-7
5-(6-(4-(4-(dimethylamino)piperidine-1-carbonyl)phenyl)imidazo[1,2-b]pyridazin-3-yl)isoindolin-1-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-Bromosuccinimide / acetonitrile / 3 h / 0 °C

2.1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

2.2: 16 h / 20 °C

3.1: caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; N,N-dimethyl-formamide / 18 h / 90 °C

With 4-methyl-morpholine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-Bromosuccinimide; caesium carbonate; HATU; In water; N,N-dimethyl-formamide; acetonitrile;