tert-butyl 5-(benzyloxy)-2-{[1-(tert-butoxycarbonyl)piperidin-4-yl]methyl}-6-{[(trifluoromethyl)sulfonyl]oxy}pyrimidine-4-carboxylate

Base Information

Chemical Name:tert-butyl 5-(benzyloxy)-2-{[1-(tert-butoxycarbonyl)piperidin-4-yl]methyl}-6-{[(trifluoromethyl)sulfonyl]oxy}pyrimidine-4-carboxylate
CAS No.:1192164-01-4
Molecular Formula:C₂₈H₃₆F₃N₃O₈S
Molecular Weight:631.67
Hs Code.:

Synonyms:tert-butyl 5-(benzyloxy)-2-{[1-(tert-butoxycarbonyl)piperidin-4-yl]methyl}-6-{[(trifluoromethyl)sulfonyl]oxy}pyrimidine-4-carboxylate

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Chemical Property of tert-butyl 5-(benzyloxy)-2-{[1-(tert-butoxycarbonyl)piperidin-4-yl]methyl}-6-{[(trifluoromethyl)sulfonyl]oxy}pyrimidine-4-carboxylate

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Technology Process of tert-butyl 5-(benzyloxy)-2-{[1-(tert-butoxycarbonyl)piperidin-4-yl]methyl}-6-{[(trifluoromethyl)sulfonyl]oxy}pyrimidine-4-carboxylate

There total 4 articles about tert-butyl 5-(benzyloxy)-2-{[1-(tert-butoxycarbonyl)piperidin-4-yl]methyl}-6-{[(trifluoromethyl)sulfonyl]oxy}pyrimidine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 358-23-6
trifluoromethylsulfonic anhydride

: 1192163-99-7
tert-butyl 5-(benzyloxy)-2-{[1-(tert-butoxycarbonyl)piperidin-4-yl]methyl}-6-hydroxypyrimidine-4-carboxylate

: 1192164-01-4
tert-butyl 5-(benzyloxy)-2-{[1-(tert-butoxycarbonyl)piperidin-4-yl]methyl}-6-{[(trifluoromethyl)sulfonyl]oxy}pyrimidine-4-carboxylate

Guidance literature:: With triethylamine; In dichloromethane; at -78 ℃; for 0.5h;

Reference yield:

: 1192164-00-3
4-tert-butyl 1-methyl 2-(benzyloxy)-3-oxosuccinate

: 1192164-01-4
tert-butyl 5-(benzyloxy)-2-{[1-(tert-butoxycarbonyl)piperidin-4-yl]methyl}-6-{[(trifluoromethyl)sulfonyl]oxy}pyrimidine-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium methylate / methanol / 14.5 h / 20 °C

2: triethylamine / dichloromethane / 0.5 h / -78 °C

With sodium methylate; triethylamine; In methanol; dichloromethane;

Reference yield:

: 31600-43-8
methyl 2-(benzyloxy)acetate

: 1192164-01-4
tert-butyl 5-(benzyloxy)-2-{[1-(tert-butoxycarbonyl)piperidin-4-yl]methyl}-6-{[(trifluoromethyl)sulfonyl]oxy}pyrimidine-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: lithium diisopropyl amide / tetrahydrofuran / -78 - -40 °C / Inert atmosphere

2: sodium methylate / methanol / 14.5 h / 20 °C

3: triethylamine / dichloromethane / 0.5 h / -78 °C

With sodium methylate; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane;