tert-butyl 5-(benzyloxy)-2-{[1-(tert-butoxycarbonyl)piperidin-4-yl]methyl}-6-hydroxypyrimidine-4-carboxylate

Base Information

Chemical Name:tert-butyl 5-(benzyloxy)-2-{[1-(tert-butoxycarbonyl)piperidin-4-yl]methyl}-6-hydroxypyrimidine-4-carboxylate
CAS No.:1192163-99-7
Molecular Formula:C₂₇H₃₇N₃O₆
Molecular Weight:499.607
Hs Code.:

Synonyms:tert-butyl 5-(benzyloxy)-2-{[1-(tert-butoxycarbonyl)piperidin-4-yl]methyl}-6-hydroxypyrimidine-4-carboxylate

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Chemical Property of tert-butyl 5-(benzyloxy)-2-{[1-(tert-butoxycarbonyl)piperidin-4-yl]methyl}-6-hydroxypyrimidine-4-carboxylate

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Technology Process of tert-butyl 5-(benzyloxy)-2-{[1-(tert-butoxycarbonyl)piperidin-4-yl]methyl}-6-hydroxypyrimidine-4-carboxylate

There total 3 articles about tert-butyl 5-(benzyloxy)-2-{[1-(tert-butoxycarbonyl)piperidin-4-yl]methyl}-6-hydroxypyrimidine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1192164-00-3
4-tert-butyl 1-methyl 2-(benzyloxy)-3-oxosuccinate

: 1192163-97-5
tert-butyl 4-(2-amino-2-iminoethyl)piperidine-1-carboxylate acetate

: 1192163-99-7
tert-butyl 5-(benzyloxy)-2-{[1-(tert-butoxycarbonyl)piperidin-4-yl]methyl}-6-hydroxypyrimidine-4-carboxylate

Guidance literature:: 4-tert-butyl 1-methyl 2-(benzyloxy)-3-oxosuccinate; tert-butyl 4-(2-amino-2-iminoethyl)piperidine-1-carboxylate acetate; With sodium methylate; In methanol; at 20 ℃; for 14.5h;

With hydrogenchloride; In methanol;

Reference yield:

: 31600-43-8
methyl 2-(benzyloxy)acetate

: 1192163-99-7
tert-butyl 5-(benzyloxy)-2-{[1-(tert-butoxycarbonyl)piperidin-4-yl]methyl}-6-hydroxypyrimidine-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: lithium diisopropyl amide / tetrahydrofuran / -78 - -40 °C / Inert atmosphere

2: sodium methylate / methanol / 14.5 h / 20 °C

With sodium methylate; lithium diisopropyl amide; In tetrahydrofuran; methanol;

Reference yield:

: 33560-65-5
oxalic acid tert-butyl ester methyl ester

: 1192163-99-7
tert-butyl 5-(benzyloxy)-2-{[1-(tert-butoxycarbonyl)piperidin-4-yl]methyl}-6-hydroxypyrimidine-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: lithium diisopropyl amide / tetrahydrofuran / -78 - -40 °C / Inert atmosphere

2: sodium methylate / methanol / 14.5 h / 20 °C

With sodium methylate; lithium diisopropyl amide; In tetrahydrofuran; methanol;