Histidylleucine zwitterion

Base Information

Chemical Name:Histidylleucine zwitterion
CAS No.:7763-65-7
Molecular Formula:C12H20N4O3
Molecular Weight:268.316
Hs Code.:2933290090
Mol file:7763-65-7.mol

Synonyms:H-L zwitterion;His-Leu zwitterion;histidylleucine zwitterion;L-His-L-Leu zwitterion;CHEBI:147392;(2S)-2-{[(2S)-2-azaniumyl-3-(1H-imidazol-4-yl)propanoyl]amino}-4-methylpentanoate

Suppliers and Price of Histidylleucine zwitterion

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Sigma-Aldrich
His-Leu
250mg
$ 274.00

Sigma-Aldrich
His-Leu
1g
$ 587.00

Crysdot
(S)-2-((S)-2-Amino-3-(1H-imidazol-4-yl)propanamido)-4-methylpentanoicacid 95+%
10g
$ 970.00

Crysdot
(S)-2-((S)-2-Amino-3-(1H-imidazol-4-yl)propanamido)-4-methylpentanoicacid 95+%
5g
$ 498.00

Chem-Impex
His-Leu-OH,99%(TLC) 99%(TLC)
100MG
$ 61.60

Chem-Impex
His-Leu-OH,≥99%(TLC) ≥99%(TLC)
250MG
$ 110.66

Chem-Impex
His-Leu-OH,99%(TLC) 99%(TLC)
1G
$ 235.20

Chemenu
(S)-2-((S)-2-Amino-3-(1H-imidazol-4-yl)propanamido)-4-methylpentanoicacid 95%
10g
$ 916.00

Chemenu
(S)-2-((S)-2-Amino-3-(1H-imidazol-4-yl)propanamido)-4-methylpentanoicacid 95%
5g
$ 636.00

Chemenu
(S)-2-((S)-2-Amino-3-(1H-imidazol-4-yl)propanamido)-4-methylpentanoicacid 95%
1g
$ 179.00

Total 32 raw suppliers

Chemical Property of Histidylleucine zwitterion

Chemical Property:

Vapor Pressure:2.21E-16mmHg at 25°C
Melting Point:217-220℃
Refractive Index:1.559
Boiling Point:623 °C at 760 mmHg
Flash Point:330.6 °C
PSA：121.10000
Density:1.249 g/cm³
LogP:0.98620
Storage Temp.:−20°C
XLogP3:-1.5
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:268.15354051
Heavy Atom Count:19
Complexity:317

Purity/Quality:

97% ^*data from raw suppliers

His-Leu ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)CC(C(=O)[O-])NC(=O)C(CC1=CN=CN1)[NH3+]
Isomeric SMILES:CC(C)C[C@@H](C(=O)[O-])NC(=O)[C@H](CC1=CN=CN1)[NH3+]

Technology Process of Histidylleucine zwitterion

There total 19 articles about Histidylleucine zwitterion which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 31373-65-6
N-α-hippuryl-L-histidyl-L-leucine

: 495-69-2,140480-84-8,21251-67-2,91787-63-2,66407-11-2
Hippuric Acid

: 7763-65-7
(S)-2-[(S)-2-Amino-3-(1H-imidazol-4-yl)-propionylamino]-4-methyl-pentanoic acid

Guidance literature:: With angiotensin I converting enzyme; In water; dimethyl sulfoxide; Rate constant; Equilibrium constant; buffer (pH 8);
DOI:10.1248/cpb.37.145

Reference yield:

: 2666-93-5
(S)-Leu-OMe

: 7763-65-7
(S)-2-[(S)-2-Amino-3-(1H-imidazol-4-yl)-propionylamino]-4-methyl-pentanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 77 percent / dicyclohexylcarbodi-imide, 1-hydroxybenzotriazole / dimethylformamide

2: 88 percent / sodium hydroxide / dioxane; H₂O / 1 h / 0 °C

3: trifluoroacetic acid

4: hydrogen / 10percent palladium-charcoal / aq. acetic acid / 15 h

With sodium hydroxide; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In 1,4-dioxane; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1039/P19810000522