Ethyl L-leucinate

Base Information

• Chemical Name: Ethyl L-leucinate
• CAS No.: 2743-60-4
• Molecular Formula: C8H17 N O2
• Molecular Weight: 159.228
• Hs Code.: 2922499990
• European Community (EC) Number: 220-377-7
• Nikkaji Number: J44.183J
• ChEMBL ID: CHEMBL51970
• Mol file: 2743-60-4.mol

Synonyms:Ethyl L-leucinate;2743-60-4;(S)-ETHYL 2-AMINO-4-METHYLPENTANOATE;Leucine ethyl ester;L-LEUCINE ETHYL ESTER;L-Leucine, ethyl ester;ethyl (2S)-2-amino-4-methylpentanoate;EINECS 220-377-7;Leucine, ethyl ester, L-;Ethyl 2-amino-4-methylpentanoate #;L-Leucine ethyl;l-leu ethyl ester;(S)-Ethyl2-amino-4-methylpentanoate;H-Leu-OEt;L-leucinyl ethyl ether;(L)-leucine, ethyl ester;(+)-L-Leucine ethyl ester;CHEMBL51970;SCHEMBL133092;AKOS010368215;AKOS015932704;EN300-6238148

Chemical Property of Ethyl L-leucinate

Chemical Property:

• Vapor Pressure: 0.515mmHg at 25°C
• Refractive Index: 1.4289
• Boiling Point: 191.4°Cat760mmHg
• PKA: 8.11±0.42(Predicted)
• Flash Point: 62.9°C
• PSA: 52.32000
• Density: 0.944g/cm³
• LogP: 1.62320
• Storage Temp.: 2-8°C
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 159.125928785
• Heavy Atom Count: 11
• Complexity: 123

Purity/Quality:

99% ^*data from raw suppliers

(S)-ethyl2-amino-4-methylpentanoate 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C(CC(C)C)N
• Isomeric SMILES: CCOC(=O)[C@H](CC(C)C)N

Technology Process of Ethyl L-leucinate

There total 12 articles about Ethyl L-leucinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethanol (64-17-5) + L-leucine (61-90-5,21675-61-6,25248-98-0,70-45-1) → L-Leucine ethyl ester (2743-60-4,75023-21-1)

Guidance literature:

With thionyl chloride;

DOI:10.1016/j.mencom.2013.03.013

Reference yield: 99.0%

L-leucine ethyl ester hydrochloride (2743-40-0) → L-Leucine ethyl ester (2743-60-4,75023-21-1)

Guidance literature:

With Amberlyst A₂₁ resin; In dichloromethane; at 0 - 20 ℃; for 2h;

DOI:10.1002/chem.202101439

Reference yield: 54.4%

→ L-Leucine ethyl ester (2743-60-4,75023-21-1)

Guidance literature:

upstream raw materials:

ethanol

L-leucine

DL-leucine ethyl ester

orthoformic acid triethyl ester

Downstream raw materials:

N-(S-benzyl-N-benzyloxycarbonyl-L-cysteinyl)-L-leucine ethyl ester

N-phenylsulfanylcarbonyl-L-leucine

N-(2-nitro-phenoxycarbonyl)-L-leucine

N-(N-phenylsulfanylcarbonyl-glycyl)-L-leucine

Refernces

• 1、 KLEINE,HANSON. "Studies on the activity and specificity of amino acid esterase activity in the crystalline lens.". . p. 106 - 115. Retrieved 1961.
• 2、 Chen, Gen-Qiang,Lang, Qi-Wei,Phansavath, Phannarath,Ratovelomanana-Vidal, Virginie,Wang, Fangyuan,Wu, Ting,Yin, Congcong,Zhang, Xumu,Zheng, Long-Sheng. "Rh(iii)-Catalyzed diastereoselective transfer hydrogenation: An efficient entry to key intermediates of HIV protease inhibitors". supporting information. p. 3119 - 3122. Retrieved 2020/03/23.
• 3、 Moshikur, Rahman Md.,Chowdhury, Md. Raihan,Wakabayashi, Rie,Tahara, Yoshiro,Moniruzzaman, Muhammad,Goto, Masahiro. "Characterization and cytotoxicity evaluation of biocompatible amino acid esters used to convert salicylic acid into ionic liquids". . p. 31 - 38. Retrieved 2018/05/28.