3-[(R)-1-(4-cyano-phenyl)-2-oxo-pyrrolidin-3-yloxy]-N-(5-methyl-4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridin-2-yl)-benzamide trifluoroacetate

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Chemical Name:3-[(R)-1-(4-cyano-phenyl)-2-oxo-pyrrolidin-3-yloxy]-N-(5-methyl-4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridin-2-yl)-benzamide trifluoroacetate
CAS No.:1354718-78-7
Molecular Formula:C₂HF₃O₂*C₂₅H₂₃N₅O₃S
Molecular Weight:587.579
Hs Code.:

Synonyms:3-[(R)-1-(4-cyano-phenyl)-2-oxo-pyrrolidin-3-yloxy]-N-(5-methyl-4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridin-2-yl)-benzamide trifluoroacetate

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Chemical Property of 3-[(R)-1-(4-cyano-phenyl)-2-oxo-pyrrolidin-3-yloxy]-N-(5-methyl-4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridin-2-yl)-benzamide trifluoroacetate

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Technology Process of 3-[(R)-1-(4-cyano-phenyl)-2-oxo-pyrrolidin-3-yloxy]-N-(5-methyl-4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridin-2-yl)-benzamide trifluoroacetate

There total 4 articles about 3-[(R)-1-(4-cyano-phenyl)-2-oxo-pyrrolidin-3-yloxy]-N-(5-methyl-4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridin-2-yl)-benzamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1354721-07-5
3-[(R)-1-(4-cyano-phenyl)-2-oxo-pyrrolidin-3-yloxy]-benzoic acid

: 17899-48-8
2-amino-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine

: 76-05-1
trifluoroacetic acid

: 1354718-78-7
3-[(R)-1-(4-cyano-phenyl)-2-oxo-pyrrolidin-3-yloxy]-N-(5-methyl-4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridin-2-yl)-benzamide trifluoroacetate

Guidance literature:: 3-[(R)-1-(4-cyano-phenyl)-2-oxo-pyrrolidin-3-yloxy]-benzoic acid; With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl acetamide; at 20 ℃; for 1h;

2-amino-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine; In N,N-dimethyl acetamide; at 50 ℃;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 19438-10-9
methyl 3-hydroxybenzoate

: 1354718-78-7
3-[(R)-1-(4-cyano-phenyl)-2-oxo-pyrrolidin-3-yloxy]-N-(5-methyl-4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridin-2-yl)-benzamide trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 - 20 °C

2.1: caesium carbonate / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 16 h / 100 °C / Inert atmosphere

3.1: water; lithium hydroxide / tetrahydrofuran / 20 °C

3.2: pH 4

4.1: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl acetamide / 1 h / 20 °C

4.2: 50 °C

With 1-hydroxy-7-aza-benzotriazole; water; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; lithium hydroxide; diethylazodicarboxylate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl acetamide;

Reference yield:

: 1354721-05-3
3-((R)-2-oxo-pyrrolidin-3-yloxy)-benzoic acid methyl ester

: 1354718-78-7
3-[(R)-1-(4-cyano-phenyl)-2-oxo-pyrrolidin-3-yloxy]-N-(5-methyl-4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridin-2-yl)-benzamide trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 16 h / 100 °C / Inert atmosphere

2.1: water; lithium hydroxide / tetrahydrofuran / 20 °C

2.2: pH 4

3.1: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl acetamide / 1 h / 20 °C

3.2: 50 °C

With 1-hydroxy-7-aza-benzotriazole; water; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl acetamide;