5-Methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-amine

Base Information

• Chemical Name: 5-Methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-amine
• CAS No.: 17899-48-8
• Molecular Formula: C7H11 N3 S
• Molecular Weight: 169.25
• Hs Code.: 2934999090
• European Community (EC) Number: 845-646-1
• DSSTox Substance ID: DTXSID90368489
• Nikkaji Number: J2.663.025H
• Wikidata: Q82155059
• ChEMBL ID: CHEMBL3410010
• Mol file: 17899-48-8.mol

Synonyms:17899-48-8;5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-amine;5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-amine;5-methyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridin-2-amine;MFCD02854749;5-Methyl-4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridin-2-ylamine;2-Amino-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine;5-methyl-4H,5H,6H,7H-[1,3]thiazolo[5,4-c]pyridin-2-amine;5-Methyl-4,5,6,7-tetrahydro[1,3]-thiazolo[5,4-c]pyridin-2-amine;SCHEMBL114205;CHEMBL3410010;DTXSID90368489;5-methyl-4H,6H,7H-[1,3]thiazolo[5,4-c]pyridin-2-amine;AMY12277;Thiazolo[5,4-c]pyridin-2-amine, 4,5,6,7-tetrahydro-5-methyl-;NSC806399;STL203986;AKOS000117244;NSC-806399;BS-13370;SY022721;BB 0261587;CS-0050438;FT-0702220;EN300-06856;J-517789;Z96092807;F3284-8052;5-Methyl-4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridin-2-amine;5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-ylamine;5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-amine;5-Methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-ylamine;5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-amine, AldrichCPR

Chemical Property of 5-Methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-amine

Chemical Property:

• Vapor Pressure: 0.000436mmHg at 25°C
• Boiling Point: 315.5°Cat760mmHg
• PKA: 6.92±0.20(Predicted)
• Flash Point: 144.6°C
• PSA: 70.39000
• Density: 1.279g/cm³
• LogP: 1.23230
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 169.06736854
• Heavy Atom Count: 11
• Complexity: 153

Purity/Quality:

97% ^*data from raw suppliers

5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1CCC2=C(C1)SC(=N2)N

Technology Process of 5-Methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-amine

There total 3 articles about 5-Methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

1-Methyl-4-piperidone (1445-73-4) + CYANAMID (420-04-2) → 2-amino-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine (17899-48-8)

Guidance literature:

With pyrrolidine; sulfur; In isopropyl alcohol; at 50 ℃; for 2h;

Reference yield: 67.8%

pyrrolidine (123-75-1) + 1-Methyl-4-piperidone (1445-73-4) → 2-amino-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine (17899-48-8)

Guidance literature:

pyrrolidine; 1-Methyl-4-piperidone; With toluene-4-sulfonic acid; In cyclohexane; for 2.5h; Reflux; Dean-Stark;

With sulfur; In methanol; at 20 ℃; for 0.166667h;

With CYANAMID; In methanol; at 0 ℃; for 5h;

DOI:10.1155/2017/3182129

Reference yield:

→ 2-amino-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine (17899-48-8)

Guidance literature:

upstream raw materials:

1-Methyl-4-piperidone

CYANAMID

pyrrolidine

Downstream raw materials:

2-Bromo-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]-pyridine

edoxaban

[14C]-Edoxaban tosylate

5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxylic acid