phosphoric acid di-tert-butyl ester 1-(di-tert-butoxyphosphoryloxymethyl)-4-(6-methylamino-2-phenylpurin-9-yl)-bicyclo[3.1.0]hex-2-yl ester

Base Information

Chemical Name:phosphoric acid di-tert-butyl ester 1-(di-tert-butoxyphosphoryloxymethyl)-4-(6-methylamino-2-phenylpurin-9-yl)-bicyclo[3.1.0]hex-2-yl ester
CAS No.:945565-64-0
Molecular Formula:C₃₅H₅₅N₅O₈P₂
Molecular Weight:735.798
Hs Code.:

Synonyms:phosphoric acid di-tert-butyl ester 1-(di-tert-butoxyphosphoryloxymethyl)-4-(6-methylamino-2-phenylpurin-9-yl)-bicyclo[3.1.0]hex-2-yl ester

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Chemical Property of phosphoric acid di-tert-butyl ester 1-(di-tert-butoxyphosphoryloxymethyl)-4-(6-methylamino-2-phenylpurin-9-yl)-bicyclo[3.1.0]hex-2-yl ester

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Technology Process of phosphoric acid di-tert-butyl ester 1-(di-tert-butoxyphosphoryloxymethyl)-4-(6-methylamino-2-phenylpurin-9-yl)-bicyclo[3.1.0]hex-2-yl ester

There total 5 articles about phosphoric acid di-tert-butyl ester 1-(di-tert-butoxyphosphoryloxymethyl)-4-(6-methylamino-2-phenylpurin-9-yl)-bicyclo[3.1.0]hex-2-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 945565-63-9
6-methylamino-2-phenyl-9H-purine

: 630103-41-2
(1'R,2'S,4'R,5'S)-phosphoric acid di-tert-butyl ester 1-(di-tert-butoxy-phosphoryloxymethyl)-4-hydroxybicyclo[3.1.0]hex-2-yl ester

: 945565-64-0
phosphoric acid di-tert-butyl ester 1-(di-tert-butoxyphosphoryloxymethyl)-4-(6-methylamino-2-phenylpurin-9-yl)-bicyclo[3.1.0]hex-2-yl ester

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 23h;
DOI:10.1021/jm0700971

Reference yield:

: 630103-54-7
2,2-dimethylpropionic acid 6-chloro-2-iodopurin-9-ylmethyl ester

: 945565-64-0
phosphoric acid di-tert-butyl ester 1-(di-tert-butoxyphosphoryloxymethyl)-4-(6-methylamino-2-phenylpurin-9-yl)-bicyclo[3.1.0]hex-2-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / Ph₃P; K₂CO₃ / Pd₂(dba)3*CHCl₃ / tetrahydrofuran; toluene / 168 h / 100 °C

2: 80 percent / tetrahydrofuran / 25 h / 20 °C

3: 90 percent / aq. NaOH / tetrahydrofuran; methanol / 3 h / 20 °C

4: 51 percent / PPh₃; DIAD / tetrahydrofuran / 23 h / 20 °C

With sodium hydroxide; di-isopropyl azodicarboxylate; potassium carbonate; triphenylphosphine; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In tetrahydrofuran; methanol; toluene; 1: Suzuki coupling / 4: Mitsunobu reaction;
DOI:10.1021/jm0700971

Reference yield:

: 98-80-6
phenylboronic acid

: 945565-64-0
phosphoric acid di-tert-butyl ester 1-(di-tert-butoxyphosphoryloxymethyl)-4-(6-methylamino-2-phenylpurin-9-yl)-bicyclo[3.1.0]hex-2-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / Ph₃P; K₂CO₃ / Pd₂(dba)3*CHCl₃ / tetrahydrofuran; toluene / 168 h / 100 °C

2: 80 percent / tetrahydrofuran / 25 h / 20 °C

3: 90 percent / aq. NaOH / tetrahydrofuran; methanol / 3 h / 20 °C

4: 51 percent / PPh₃; DIAD / tetrahydrofuran / 23 h / 20 °C

With sodium hydroxide; di-isopropyl azodicarboxylate; potassium carbonate; triphenylphosphine; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In tetrahydrofuran; methanol; toluene; 1: Suzuki coupling / 4: Mitsunobu reaction;
DOI:10.1021/jm0700971