2,2-dimethylpropionic acid 6-methylamino-2-phenylpurin-9-ylmethyl ester

Base Information

Chemical Name:2,2-dimethylpropionic acid 6-methylamino-2-phenylpurin-9-ylmethyl ester
CAS No.:1027992-42-2
Molecular Formula:C₁₈H₂₁N₅O₂
Molecular Weight:339.397
Hs Code.:

Synonyms:2,2-dimethylpropionic acid 6-methylamino-2-phenylpurin-9-ylmethyl ester

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Chemical Property of 2,2-dimethylpropionic acid 6-methylamino-2-phenylpurin-9-ylmethyl ester

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Technology Process of 2,2-dimethylpropionic acid 6-methylamino-2-phenylpurin-9-ylmethyl ester

There total 3 articles about 2,2-dimethylpropionic acid 6-methylamino-2-phenylpurin-9-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1026307-88-9
2,2-dimethylpropionic acid 6-chloro-2-phenylpurin-9-ylmethyl ester

: 74-89-5
methylamine

: 1027992-42-2
2,2-dimethylpropionic acid 6-methylamino-2-phenylpurin-9-ylmethyl ester

Guidance literature:: In tetrahydrofuran; at 20 ℃; for 25h;
DOI:10.1021/jm0700971

Reference yield:

: 630103-54-7
2,2-dimethylpropionic acid 6-chloro-2-iodopurin-9-ylmethyl ester

: 1027992-42-2
2,2-dimethylpropionic acid 6-methylamino-2-phenylpurin-9-ylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / Ph₃P; K₂CO₃ / Pd₂(dba)3*CHCl₃ / tetrahydrofuran; toluene / 168 h / 100 °C

2: 80 percent / tetrahydrofuran / 25 h / 20 °C

With potassium carbonate; triphenylphosphine; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In tetrahydrofuran; toluene; 1: Suzuki coupling;
DOI:10.1021/jm0700971

Reference yield:

: 98-80-6
phenylboronic acid

: 1027992-42-2
2,2-dimethylpropionic acid 6-methylamino-2-phenylpurin-9-ylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / Ph₃P; K₂CO₃ / Pd₂(dba)3*CHCl₃ / tetrahydrofuran; toluene / 168 h / 100 °C

2: 80 percent / tetrahydrofuran / 25 h / 20 °C

With potassium carbonate; triphenylphosphine; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In tetrahydrofuran; toluene; 1: Suzuki coupling;
DOI:10.1021/jm0700971