4-chloro-N-(1-(1-(2-cyanoacetyl)piperidin-3-yl)-1H-benzo[d]imidazol-2-yl)benzamide

Base Information

Chemical Name:4-chloro-N-(1-(1-(2-cyanoacetyl)piperidin-3-yl)-1H-benzo[d]imidazol-2-yl)benzamide
CAS No.:1575819-20-3
Molecular Formula:C₂₂H₂₀ClN₅O₂
Molecular Weight:421.886
Hs Code.:

Synonyms:4-chloro-N-(1-(1-(2-cyanoacetyl)piperidin-3-yl)-1H-benzo[d]imidazol-2-yl)benzamide

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Chemical Property of 4-chloro-N-(1-(1-(2-cyanoacetyl)piperidin-3-yl)-1H-benzo[d]imidazol-2-yl)benzamide

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Technology Process of 4-chloro-N-(1-(1-(2-cyanoacetyl)piperidin-3-yl)-1H-benzo[d]imidazol-2-yl)benzamide

There total 7 articles about 4-chloro-N-(1-(1-(2-cyanoacetyl)piperidin-3-yl)-1H-benzo[d]imidazol-2-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1575819-19-0
4-chloro-N-(1-(piperidin-3-yl)-1H-benzo[d]imidazol-2-yl)benzamide hydrochloride

: 372-09-8
cyanoacetic acid

: 1575819-20-3
4-chloro-N-(1-(1-(2-cyanoacetyl)piperidin-3-yl)-1H-benzo[d]imidazol-2-yl)benzamide

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; at 0 - 20 ℃; for 16h; Inert atmosphere;

Reference yield:

: 1575819-17-8
tert-butyl 3-(2-imino-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidine-1-carboxylate

: 1575819-20-3
4-chloro-N-(1-(1-(2-cyanoacetyl)piperidin-3-yl)-1H-benzo[d]imidazol-2-yl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 16 h / 20 °C / Inert atmosphere

2: hydrogenchloride / 1,4-dioxane / 16 h / 10 - 20 °C / Inert atmosphere

3: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 16 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: tert-butyl 3-(2-nitrophenylamino)-piperidine-1-carboxylate

: 1575819-20-3
4-chloro-N-(1-(1-(2-cyanoacetyl)piperidin-3-yl)-1H-benzo[d]imidazol-2-yl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogen; palladium 10% on activated carbon / methanol / 2 h / 20 °C / Inert atmosphere

2: ethanol / 2 h / 20 °C

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 16 h / 20 °C / Inert atmosphere

4: hydrogenchloride / 1,4-dioxane / 16 h / 10 - 20 °C / Inert atmosphere

5: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 16 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;