tert-butyl N-methyl-[6-methoxy-9-(3-trifluoromethyl phenylsulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl] carbamate

Base Information

Chemical Name:tert-butyl N-methyl-[6-methoxy-9-(3-trifluoromethyl phenylsulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl] carbamate
CAS No.:1414848-12-6
Molecular Formula:C₂₆H₂₉F₃N₂O₅S
Molecular Weight:538.588
Hs Code.:

Synonyms:tert-butyl N-methyl-[6-methoxy-9-(3-trifluoromethyl phenylsulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl] carbamate

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Chemical Property of tert-butyl N-methyl-[6-methoxy-9-(3-trifluoromethyl phenylsulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl] carbamate

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Technology Process of tert-butyl N-methyl-[6-methoxy-9-(3-trifluoromethyl phenylsulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl] carbamate

There total 4 articles about tert-butyl N-methyl-[6-methoxy-9-(3-trifluoromethyl phenylsulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl] carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1414848-10-4
tert-butyl N-methyl-(6-methoxy-2,3,4,9-tetrahydro-1H-carbazol-3-yl)carbamate

: 777-44-6
3-(Trifluoromethyl)benzenesulfonyl chloride

: 1414848-12-6
tert-butyl N-methyl-[6-methoxy-9-(3-trifluoromethyl phenylsulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl] carbamate

Guidance literature:: tert-butyl N-methyl-(6-methoxy-2,3,4,9-tetrahydro-1H-carbazol-3-yl)carbamate; With potassium hydride; In tetrahydrofuran; mineral oil; at 25 ℃; for 1h;

3-(Trifluoromethyl)benzenesulfonyl chloride; In tetrahydrofuran; mineral oil; at 25 ℃; for 2h;
DOI:10.1016/j.bmcl.2012.06.002

Reference yield:

: 1414847-17-8
N-methyl-(6-methoxy-2,3,4,9-tetrahydro-1H-carbazol-3-yl)amine

: 1414848-12-6
tert-butyl N-methyl-[6-methoxy-9-(3-trifluoromethyl phenylsulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl] carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 2 h / 10 °C

2.1: potassium hydride / tetrahydrofuran; mineral oil / 1 h / 25 °C

2.2: 2 h / 25 °C

With potassium hydride; triethylamine; In tetrahydrofuran; dichloromethane; mineral oil;
DOI:10.1016/j.bmcl.2012.06.002

Reference yield:

: 4746-97-8
cyclohexanedione monoethylene ketal

: 1414848-12-6
tert-butyl N-methyl-[6-methoxy-9-(3-trifluoromethyl phenylsulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl] carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: deuteromethanol / 2 h / 20 °C

1.2: 18 h / 25 - 30 °C / pH Ca_. 6

2.1: sulfuric acid / water / 95 - 100 °C

3.1: triethylamine / dichloromethane / 2 h / 10 °C

4.1: potassium hydride / tetrahydrofuran; mineral oil / 1 h / 25 °C

4.2: 2 h / 25 °C

With sulfuric acid; potassium hydride; triethylamine; In tetrahydrofuran; dichloromethane; deuteromethanol; water; mineral oil;
DOI:10.1016/j.bmcl.2012.06.002