(E)-3-<2-butyl-1-<(4-carboxamidophenyl)methyl>imidazol-5-yl>-2-(2-thienylmethyl)-2-propenamide

Base Information

Chemical Name:(E)-3-<2-butyl-1-<(4-carboxamidophenyl)methyl>imidazol-5-yl>-2-(2-thienylmethyl)-2-propenamide
CAS No.:133486-07-4
Molecular Formula:C₂₃H₂₆N₄O₂S
Molecular Weight:422.551
Hs Code.:

Synonyms:(E)-3-<2-butyl-1-<(4-carboxamidophenyl)methyl>imidazol-5-yl>-2-(2-thienylmethyl)-2-propenamide

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Chemical Property of (E)-3-<2-butyl-1-<(4-carboxamidophenyl)methyl>imidazol-5-yl>-2-(2-thienylmethyl)-2-propenamide

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Technology Process of (E)-3-<2-butyl-1-<(4-carboxamidophenyl)methyl>imidazol-5-yl>-2-(2-thienylmethyl)-2-propenamide

There total 12 articles about (E)-3-<2-butyl-1-<(4-carboxamidophenyl)methyl>imidazol-5-yl>-2-(2-thienylmethyl)-2-propenamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2417-72-3
Methyl 4-(bromomethyl)benzoate

: 133486-07-4
(E)-3-<2-butyl-1-<(4-carboxamidophenyl)methyl>imidazol-5-yl>-2-(2-thienylmethyl)-2-propenamide

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 70 °C

2: manganese(IV) oxide; hydrogen; potassium acetate / palladium on activated charcoal / 1.) MeOH, 40 psi, 1.25 h, 2.) CH₂Cl₂, reflux

3: piperidine; benzoic acid / toluene / 18 h / Heating

4: sodium hydroxide / methanol / 18 h / Heating

5: thionyl chloride / benzene / 2.5 h / 55 °C

6: ammonium hydroxide / 1.5 h / Ambient temperature

With piperidine; manganese(IV) oxide; ammonium hydroxide; sodium hydroxide; thionyl chloride; hydrogen; potassium acetate; potassium carbonate; benzoic acid; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide; toluene; benzene;
DOI:10.1021/jm00065a011

Reference yield:

: 83857-96-9
2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde

: 133486-07-4
(E)-3-<2-butyl-1-<(4-carboxamidophenyl)methyl>imidazol-5-yl>-2-(2-thienylmethyl)-2-propenamide

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 70 °C

2: manganese(IV) oxide; hydrogen; potassium acetate / palladium on activated charcoal / 1.) MeOH, 40 psi, 1.25 h, 2.) CH₂Cl₂, reflux

3: piperidine; benzoic acid / toluene / 18 h / Heating

4: sodium hydroxide / methanol / 18 h / Heating

5: thionyl chloride / benzene / 2.5 h / 55 °C

6: ammonium hydroxide / 1.5 h / Ambient temperature

With piperidine; manganese(IV) oxide; ammonium hydroxide; sodium hydroxide; thionyl chloride; hydrogen; potassium acetate; potassium carbonate; benzoic acid; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide; toluene; benzene;
DOI:10.1021/jm00065a011

Reference yield:

: 133040-02-5
2-butyl-4-chloro-1-<(4-carbomethoxyphenyl)methyl>-1H-imidazole-5-carboxaldehyde

: 133486-07-4
(E)-3-<2-butyl-1-<(4-carboxamidophenyl)methyl>imidazol-5-yl>-2-(2-thienylmethyl)-2-propenamide

Guidance literature:: Multi-step reaction with 5 steps

1: manganese(IV) oxide; hydrogen; potassium acetate / palladium on activated charcoal / 1.) MeOH, 40 psi, 1.25 h, 2.) CH₂Cl₂, reflux

2: piperidine; benzoic acid / toluene / 18 h / Heating

3: sodium hydroxide / methanol / 18 h / Heating

4: thionyl chloride / benzene / 2.5 h / 55 °C

5: ammonium hydroxide / 1.5 h / Ambient temperature

With piperidine; manganese(IV) oxide; ammonium hydroxide; sodium hydroxide; thionyl chloride; hydrogen; potassium acetate; benzoic acid; palladium on activated charcoal; In methanol; toluene; benzene;
DOI:10.1021/jm00065a011