Technology Process of (E)-3-<2-butyl-1-<(4-carboxamidophenyl)methyl>imidazol-5-yl>-2-(2-thienylmethyl)-2-propenamide
There total 12 articles about (E)-3-<2-butyl-1-<(4-carboxamidophenyl)methyl>imidazol-5-yl>-2-(2-thienylmethyl)-2-propenamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 70 °C
2: manganese(IV) oxide; hydrogen; potassium acetate / palladium on activated charcoal / 1.) MeOH, 40 psi, 1.25 h, 2.) CH2Cl2, reflux
3: piperidine; benzoic acid / toluene / 18 h / Heating
4: sodium hydroxide / methanol / 18 h / Heating
5: thionyl chloride / benzene / 2.5 h / 55 °C
6: ammonium hydroxide / 1.5 h / Ambient temperature
With
piperidine; manganese(IV) oxide; ammonium hydroxide; sodium hydroxide; thionyl chloride; hydrogen; potassium acetate; potassium carbonate; benzoic acid;
palladium on activated charcoal;
In
methanol; N,N-dimethyl-formamide; toluene; benzene;
DOI:10.1021/jm00065a011
- Guidance literature:
-
Multi-step reaction with 6 steps
1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 70 °C
2: manganese(IV) oxide; hydrogen; potassium acetate / palladium on activated charcoal / 1.) MeOH, 40 psi, 1.25 h, 2.) CH2Cl2, reflux
3: piperidine; benzoic acid / toluene / 18 h / Heating
4: sodium hydroxide / methanol / 18 h / Heating
5: thionyl chloride / benzene / 2.5 h / 55 °C
6: ammonium hydroxide / 1.5 h / Ambient temperature
With
piperidine; manganese(IV) oxide; ammonium hydroxide; sodium hydroxide; thionyl chloride; hydrogen; potassium acetate; potassium carbonate; benzoic acid;
palladium on activated charcoal;
In
methanol; N,N-dimethyl-formamide; toluene; benzene;
DOI:10.1021/jm00065a011
- Guidance literature:
-
Multi-step reaction with 5 steps
1: manganese(IV) oxide; hydrogen; potassium acetate / palladium on activated charcoal / 1.) MeOH, 40 psi, 1.25 h, 2.) CH2Cl2, reflux
2: piperidine; benzoic acid / toluene / 18 h / Heating
3: sodium hydroxide / methanol / 18 h / Heating
4: thionyl chloride / benzene / 2.5 h / 55 °C
5: ammonium hydroxide / 1.5 h / Ambient temperature
With
piperidine; manganese(IV) oxide; ammonium hydroxide; sodium hydroxide; thionyl chloride; hydrogen; potassium acetate; benzoic acid;
palladium on activated charcoal;
In
methanol; toluene; benzene;
DOI:10.1021/jm00065a011
