tert-butyl-{5-[hydroxy(3-trifluoromethylphenyl)methyl]thiazol-2-yl}carbamate

Base Information

• Chemical Name: tert-butyl-{5-[hydroxy(3-trifluoromethylphenyl)methyl]thiazol-2-yl}carbamate
• CAS No.: 1081314-08-0
• Molecular Formula: C₁₆H₁₇F₃N₂O₃S
• Molecular Weight: 374.384
• Mol file: 1081314-08-0.mol

Synonyms:tert-butyl-{5-[hydroxy(3-trifluoromethylphenyl)methyl]thiazol-2-yl}carbamate

Chemical Property of tert-butyl-{5-[hydroxy(3-trifluoromethylphenyl)methyl]thiazol-2-yl}carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl-{5-[hydroxy(3-trifluoromethylphenyl)methyl]thiazol-2-yl}carbamate

There total 2 articles about tert-butyl-{5-[hydroxy(3-trifluoromethylphenyl)methyl]thiazol-2-yl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

3-Trifluoromethylbenzaldehyde (454-89-7) + tert-butyl 5-bromothiazol-2-ylcarbamate (405939-39-1) → tert-butyl-{5-[hydroxy(3-trifluoromethylphenyl)methyl]thiazol-2-yl}carbamate (1081314-08-0)

Guidance literature:

tert-butyl 5-bromothiazol-2-ylcarbamate; With n-butyllithium; In tetrahydrofuran;

3-Trifluoromethylbenzaldehyde; In tetrahydrofuran; at -78 - 5 ℃;

DOI:10.1016/j.bmcl.2009.05.123

Reference yield: 31.0%

3-Trifluoromethylbenzaldehyde (454-89-7) + tert-butyl 1,3-thiazole-2-yl-carbamate (170961-15-6) → tert-butyl-{5-[hydroxy(3-trifluoromethylphenyl)methyl]thiazol-2-yl}carbamate (1081314-08-0)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 2h; Inert atmosphere;

DOI:10.1016/j.bmc.2014.12.006

Reference yield: 71.0%

tert-butyl-{5-[hydroxy(3-trifluoromethylphenyl)methyl]thiazol-2-yl}carbamate (1081314-08-0) → C16H15F3N2O3S (1081314-09-1)

Guidance literature:

With Dess-Martin periodane; In dichloromethane;

DOI:10.1016/j.bmcl.2009.05.123

upstream raw materials:

3-Trifluoromethylbenzaldehyde

tert-butyl 5-bromothiazol-2-ylcarbamate

tert-butyl 1,3-thiazole-2-yl-carbamate

Downstream raw materials:

C₁₆H₁₅F₃N₂O₃S

2-amino-5-(3-trifluoromethylbenzyl)-1,3-thiazole