N-[[(4R)-4-cyclopropyl-2,5-dioxo-imidazolidin-4-yl]methyl]-2,2-dimethyl-3-[4-(trifluoromethyl)phenyl]propanamide

Base Information

Chemical Name:N-[[(4R)-4-cyclopropyl-2,5-dioxo-imidazolidin-4-yl]methyl]-2,2-dimethyl-3-[4-(trifluoromethyl)phenyl]propanamide
CAS No.:1607004-37-4
Molecular Formula:C₁₉H₂₂F₃N₃O₃
Molecular Weight:397.397
Hs Code.:

Synonyms:N-[[(4R)-4-cyclopropyl-2,5-dioxo-imidazolidin-4-yl]methyl]-2,2-dimethyl-3-[4-(trifluoromethyl)phenyl]propanamide

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Chemical Property of N-[[(4R)-4-cyclopropyl-2,5-dioxo-imidazolidin-4-yl]methyl]-2,2-dimethyl-3-[4-(trifluoromethyl)phenyl]propanamide

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Technology Process of N-[[(4R)-4-cyclopropyl-2,5-dioxo-imidazolidin-4-yl]methyl]-2,2-dimethyl-3-[4-(trifluoromethyl)phenyl]propanamide

There total 10 articles about N-[[(4R)-4-cyclopropyl-2,5-dioxo-imidazolidin-4-yl]methyl]-2,2-dimethyl-3-[4-(trifluoromethyl)phenyl]propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1439896-97-5
2,2-dimethyl-3-[4-(trifluoromethyl)phenyl]propanoic acid

: (5R)-5-(aminomethyl)-5-cyclopropyl-imidazolidine-2,4-dione hydrochloride

: 1607004-37-4
N-[[(4R)-4-cyclopropyl-2,5-dioxo-imidazolidin-4-yl]methyl]-2,2-dimethyl-3-[4-(trifluoromethyl)phenyl]propanamide

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diisopropylamine; In acetonitrile; at 20 ℃; for 12h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.7b00650

Reference yield:

: 1439896-97-5
2,2-dimethyl-3-[4-(trifluoromethyl)phenyl]propanoic acid

: 1607004-45-4
tert-butyl N-[[(4R)-4-cyclopropyl-2,5-dioxo-imidazolidin-4-yl]methyl]carbamate

: 1607004-37-4
N-[[(4R)-4-cyclopropyl-2,5-dioxo-imidazolidin-4-yl]methyl]-2,2-dimethyl-3-[4-(trifluoromethyl)phenyl]propanamide

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; N,N-diiodopropylethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In acetonitrile; at 20 ℃; for 12h;

Reference yield:

: 455-19-6
4-Trifluoromethylbenzaldehyde

: 1607004-37-4
N-[[(4R)-4-cyclopropyl-2,5-dioxo-imidazolidin-4-yl]methyl]-2,2-dimethyl-3-[4-(trifluoromethyl)phenyl]propanamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / tetrahydrofuran / 12 h / 0 - 20 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / methanol / 16 h / 760.05 Torr / Inert atmosphere

3.1: lithium diisopropyl amide / tetrahydrofuran / 0.17 h / -78 °C

3.2: 0.25 h / -78 °C

4.1: water; sodium hydroxide / methanol / 3 h / 80 °C

5.1: N,N-diiodopropylethylamine; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 12 h / 20 °C

With 1-hydroxy-7-aza-benzotriazole; palladium 10% on activated carbon; N,N-diiodopropylethylamine; water; hydrogen; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; methanol; acetonitrile;