4-(5-(2-(diethylamino)-6-methylpyridin-4-yl)-1,2,4-oxadiazol-3-yl)-2-ethyl-6-methylphenol

Base Information

Chemical Name:4-(5-(2-(diethylamino)-6-methylpyridin-4-yl)-1,2,4-oxadiazol-3-yl)-2-ethyl-6-methylphenol
CAS No.:1062669-89-9
Molecular Formula:C₂₁H₂₆N₄O₂
Molecular Weight:366.463
Hs Code.:

Synonyms:4-(5-(2-(diethylamino)-6-methylpyridin-4-yl)-1,2,4-oxadiazol-3-yl)-2-ethyl-6-methylphenol

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Chemical Property of 4-(5-(2-(diethylamino)-6-methylpyridin-4-yl)-1,2,4-oxadiazol-3-yl)-2-ethyl-6-methylphenol

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Technology Process of 4-(5-(2-(diethylamino)-6-methylpyridin-4-yl)-1,2,4-oxadiazol-3-yl)-2-ethyl-6-methylphenol

There total 12 articles about 4-(5-(2-(diethylamino)-6-methylpyridin-4-yl)-1,2,4-oxadiazol-3-yl)-2-ethyl-6-methylphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 910635-33-5
3-ethyl-N,4-dihydroxy-5-methylbenzimidamide

: 1062668-88-5
2-(diethylamino)-6-methylisonicotinic acid hydrochloride

: 1062669-89-9
4-(5-(2-(diethylamino)-6-methylpyridin-4-yl)-1,2,4-oxadiazol-3-yl)-2-ethyl-6-methylphenol

Guidance literature:: 3-ethyl-N,4-dihydroxy-5-methylbenzimidamide; 2-(diethylamino)-6-methylisonicotinic acid hydrochloride; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; Inert atmosphere;

In 1,4-dioxane; at 80 - 100 ℃; Reagent/catalyst; Inert atmosphere;
DOI:10.1021/jm4014696

Reference yield:

: 1365337-59-2
C₁₀H₁₃NO₂

: 1062669-89-9
4-(5-(2-(diethylamino)-6-methylpyridin-4-yl)-1,2,4-oxadiazol-3-yl)-2-ethyl-6-methylphenol

Guidance literature:: Multi-step reaction with 4 steps

1: trichloromethyl chloroformate / acetonitrile / Reflux

2: hydroxylamine hydrochloride; triethylamine / methanol / 7.5 h / 65 °C / Large scale reaction

3: benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide / tetrahydrofuran / 2 h / -5 - 0 °C

4: tetrahydrofuran / 30 h / Reflux

With hydroxylamine hydrochloride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; trichloromethyl chloroformate; In tetrahydrofuran; methanol; acetonitrile;
DOI:10.1021/op200326s

Reference yield:

: 1150644-73-7
4-amino-3-ethyl-5-methylbenzonitrile

: 1062669-89-9
4-(5-(2-(diethylamino)-6-methylpyridin-4-yl)-1,2,4-oxadiazol-3-yl)-2-ethyl-6-methylphenol

Guidance literature:: Multi-step reaction with 4 steps

1: sulfuric acid; sodium nitrite / water; acetonitrile / 0.5 h / 50 - 55 °C

2: hydroxylamine hydrochloride; triethylamine / methanol / 7.5 h / 65 °C / Large scale reaction

3: benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide / tetrahydrofuran / 2 h / -5 - 0 °C

4: tetrahydrofuran / 30 h / Reflux

With sulfuric acid; hydroxylamine hydrochloride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; sodium nitrite; In tetrahydrofuran; methanol; water; acetonitrile;
DOI:10.1021/op200326s