Technology Process of 4-(5-(2-(diethylamino)-6-methylpyridin-4-yl)-1,2,4-oxadiazol-3-yl)-2-ethyl-6-methylphenol
There total 12 articles about 4-(5-(2-(diethylamino)-6-methylpyridin-4-yl)-1,2,4-oxadiazol-3-yl)-2-ethyl-6-methylphenol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
3-ethyl-N,4-dihydroxy-5-methylbenzimidamide; 2-(diethylamino)-6-methylisonicotinic acid hydrochloride;
With
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at 20 ℃;
Inert atmosphere;
In
1,4-dioxane;
at 80 - 100 ℃;
Reagent/catalyst;
Inert atmosphere;
DOI:10.1021/jm4014696
- Guidance literature:
-
Multi-step reaction with 4 steps
1: trichloromethyl chloroformate / acetonitrile / Reflux
2: hydroxylamine hydrochloride; triethylamine / methanol / 7.5 h / 65 °C / Large scale reaction
3: benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide / tetrahydrofuran / 2 h / -5 - 0 °C
4: tetrahydrofuran / 30 h / Reflux
With
hydroxylamine hydrochloride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; trichloromethyl chloroformate;
In
tetrahydrofuran; methanol; acetonitrile;
DOI:10.1021/op200326s
- Guidance literature:
-
Multi-step reaction with 4 steps
1: sulfuric acid; sodium nitrite / water; acetonitrile / 0.5 h / 50 - 55 °C
2: hydroxylamine hydrochloride; triethylamine / methanol / 7.5 h / 65 °C / Large scale reaction
3: benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide / tetrahydrofuran / 2 h / -5 - 0 °C
4: tetrahydrofuran / 30 h / Reflux
With
sulfuric acid; hydroxylamine hydrochloride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; sodium nitrite;
In
tetrahydrofuran; methanol; water; acetonitrile;
DOI:10.1021/op200326s
