Technology Process of 5-(4-methoxybenzyl)-2-phenyl-2,3-dihydrobenzo[b][1,4]thiazepin-4(5H)-one
There total 6 articles about 5-(4-methoxybenzyl)-2-phenyl-2,3-dihydrobenzo[b][1,4]thiazepin-4(5H)-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2,3-dihydro-2-phenyl-1,5-benzothiazepin-4(5H)-one;
With
sodium hydride;
In
N,N-dimethyl-formamide;
at -10 ℃;
for 0.5h;
4-methoxybenzyl halide;
In
N,N-dimethyl-formamide;
at -10 ℃;
DOI:10.1016/j.ejmech.2012.09.021
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: pyridine; piperidine / 2 h / Reflux
2.1: 6 h / 180 °C / Molecular sieve; Inert atmosphere
3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / -10 °C
3.2: -10 °C
With
piperidine; pyridine; sodium hydride;
In
N,N-dimethyl-formamide;
1.1: |Knoevenagel Condensation;
DOI:10.1016/j.ejmech.2012.09.021
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 6 h / 180 °C / Molecular sieve; Inert atmosphere
2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / -10 °C
2.2: -10 °C
With
sodium hydride;
In
N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2012.09.021