5-[4-({3-chloro-4-[(2-fluorobenzyl)oxy]phenyl}amino)quinazoline-6-yl]furan-2-carbaldehyde

Base Information

Chemical Name:5-[4-({3-chloro-4-[(2-fluorobenzyl)oxy]phenyl}amino)quinazoline-6-yl]furan-2-carbaldehyde
CAS No.:1393112-44-1
Molecular Formula:C₂₆H₁₇ClFN₃O₃
Molecular Weight:473.891
Hs Code.:

Synonyms:5-[4-({3-chloro-4-[(2-fluorobenzyl)oxy]phenyl}amino)quinazoline-6-yl]furan-2-carbaldehyde

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Chemical Property of 5-[4-({3-chloro-4-[(2-fluorobenzyl)oxy]phenyl}amino)quinazoline-6-yl]furan-2-carbaldehyde

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Technology Process of 5-[4-({3-chloro-4-[(2-fluorobenzyl)oxy]phenyl}amino)quinazoline-6-yl]furan-2-carbaldehyde

There total 6 articles about 5-[4-({3-chloro-4-[(2-fluorobenzyl)oxy]phenyl}amino)quinazoline-6-yl]furan-2-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.8%

: 27329-70-0
5-formylfurane-2-boronic acid

: 1393112-43-0
N-{3-chloro-4-[(2-fluorobenzyl)oxy]phenyl}-6-iodoquinazoline-4-amine hydrochloride

: 1393112-44-1
5-[4-({3-chloro-4-[(2-fluorobenzyl)oxy]phenyl}amino)quinazoline-6-yl]furan-2-carbaldehyde

Guidance literature:: With potassium carbonate; palladium diacetate; In tetrahydrofuran; ethanol; at 75 ℃; for 1h; Inert atmosphere;

Reference yield:

: 619-08-9
2-chloro-4-nitrophenol

: 1393112-44-1
5-[4-({3-chloro-4-[(2-fluorobenzyl)oxy]phenyl}amino)quinazoline-6-yl]furan-2-carbaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetonitrile / 2 h / 60 °C / Inert atmosphere

2: iron; ammonium chloride; water / ethanol; methanol / 2 h / 68 °C / Inert atmosphere

3: isopropyl alcohol / 2 h / 70 °C / Inert atmosphere

4: potassium carbonate; palladium diacetate / ethanol; tetrahydrofuran / 1 h / 75 °C / Inert atmosphere

With water; palladium diacetate; iron; potassium carbonate; ammonium chloride; In tetrahydrofuran; methanol; ethanol; isopropyl alcohol; acetonitrile;

Reference yield:

: 446-48-0
o-fluorobenzyl bromide

: 1393112-44-1
5-[4-({3-chloro-4-[(2-fluorobenzyl)oxy]phenyl}amino)quinazoline-6-yl]furan-2-carbaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetonitrile / 2 h / 60 °C / Inert atmosphere

2: iron; ammonium chloride; water / ethanol; methanol / 2 h / 68 °C / Inert atmosphere

3: isopropyl alcohol / 2 h / 70 °C / Inert atmosphere

4: potassium carbonate; palladium diacetate / ethanol; tetrahydrofuran / 1 h / 75 °C / Inert atmosphere

With water; palladium diacetate; iron; potassium carbonate; ammonium chloride; In tetrahydrofuran; methanol; ethanol; isopropyl alcohol; acetonitrile;