N-{3-chloro-4-[(2-fluorobenzyl)oxy]phenyl}-6-iodoquinazoline-4-amine hydrochloride

Base Information

Chemical Name:N-{3-chloro-4-[(2-fluorobenzyl)oxy]phenyl}-6-iodoquinazoline-4-amine hydrochloride
CAS No.:1393112-43-0
Molecular Formula:C₂₁H₁₄ClFIN₃O*ClH
Molecular Weight:542.179
Hs Code.:

Synonyms:N-{3-chloro-4-[(2-fluorobenzyl)oxy]phenyl}-6-iodoquinazoline-4-amine hydrochloride

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Chemical Property of N-{3-chloro-4-[(2-fluorobenzyl)oxy]phenyl}-6-iodoquinazoline-4-amine hydrochloride

Chemical Property:

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Technology Process of N-{3-chloro-4-[(2-fluorobenzyl)oxy]phenyl}-6-iodoquinazoline-4-amine hydrochloride

There total 5 articles about N-{3-chloro-4-[(2-fluorobenzyl)oxy]phenyl}-6-iodoquinazoline-4-amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.7%

: 98556-31-1
4-chloro-6-iodoquinazoline

: 179246-45-8
4-(2-fluorobenzyloxy)-3-chlorobenzenamine

: 1393112-43-0
N-{3-chloro-4-[(2-fluorobenzyl)oxy]phenyl}-6-iodoquinazoline-4-amine hydrochloride

Guidance literature:: In isopropyl alcohol; at 70 ℃; for 2h; Inert atmosphere;

Reference yield:

: 619-08-9
2-chloro-4-nitrophenol

: 1393112-43-0
N-{3-chloro-4-[(2-fluorobenzyl)oxy]phenyl}-6-iodoquinazoline-4-amine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / 2 h / 60 °C / Inert atmosphere

2: iron; ammonium chloride; water / ethanol; methanol / 2 h / 68 °C / Inert atmosphere

3: isopropyl alcohol / 2 h / 70 °C / Inert atmosphere

With water; iron; potassium carbonate; ammonium chloride; In methanol; ethanol; isopropyl alcohol; acetonitrile;

Reference yield:

: 446-48-0
o-fluorobenzyl bromide

: 1393112-43-0
N-{3-chloro-4-[(2-fluorobenzyl)oxy]phenyl}-6-iodoquinazoline-4-amine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / 2 h / 60 °C / Inert atmosphere

2: iron; ammonium chloride; water / ethanol; methanol / 2 h / 68 °C / Inert atmosphere

3: isopropyl alcohol / 2 h / 70 °C / Inert atmosphere

With water; iron; potassium carbonate; ammonium chloride; In methanol; ethanol; isopropyl alcohol; acetonitrile;