(5-amino-2-butyl-1-benzofuran-3-yl)(4-hydroxyphenyl)methanone

Base Information

• Chemical Name: (5-amino-2-butyl-1-benzofuran-3-yl)(4-hydroxyphenyl)methanone
• CAS No.: 1278585-68-4
• Molecular Formula: C₁₉H₁₉NO₃
• Molecular Weight: 309.365
• Hs Code.: 2932996560
• Mol file: 1278585-68-4.mol

Synonyms:(5-amino-2-butyl-1-benzofuran-3-yl)(4-hydroxyphenyl)methanone

Chemical Property of (5-amino-2-butyl-1-benzofuran-3-yl)(4-hydroxyphenyl)methanone

Chemical Property:

Purity/Quality:

≥95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (5-amino-2-butyl-1-benzofuran-3-yl)(4-hydroxyphenyl)methanone

There total 1 articles about (5-amino-2-butyl-1-benzofuran-3-yl)(4-hydroxyphenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.3%

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran (141645-16-1) → (5-amino-2-butyl-1-benzofuran-3-yl)(4-hydroxyphenyl)methanone (1278585-68-4)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; at 50 ℃; for 6h; under 3750.38 Torr;

Reference yield: 86.4%

(5-amino-2-butyl-1-benzofuran-3-yl)(4-hydroxyphenyl)methanone (1278585-68-4) + methanesulfonyl chloride (124-63-0) → N-[2-butyl-3-(4-hydroxybenzoyl)-1-benzofuran-5-yl]methanesulfonamide (1278585-70-8)

Guidance literature:

With pyridine; In dichloromethane; at 30 - 35 ℃; for 0.5h;

Reference yield:

(5-amino-2-butyl-1-benzofuran-3-yl)(4-hydroxyphenyl)methanone (1278585-68-4) → dronedarone (141626-36-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: pyridine / dichloromethane / 0.5 h / 30 - 35 °C

2.1: pyridine / dichloromethane / 2 h / 10 - 12 °C

3.1: potassium carbonate; sodium iodide / butanone / 0.17 h / 20 °C

3.2: 5 h / 80 - 90 °C

4.1: sodium hydroxide / methanol / 1 h / Reflux

5.1: borane-THF / tetrahydrofuran / 1.25 h / 0 °C / Reflux

With pyridine; borane-THF; potassium carbonate; sodium iodide; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; butanone;

upstream raw materials:

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran

Downstream raw materials:

dronedarone

N,N-dibutyl-3-[4-((2-butyl-5-[(methylsulfonyl)amino]-1-benzofuran-3-yl)carbonyl)-phenoxy]propanamide

N-(2-butyl-3-[(4-hydroxyphenyl)carbonyl]-1-benzofuran-5-yl)-N-(methylsulfonyl)-benzamide

N-[2-butyl-3-(4-hydroxybenzoyl)-1-benzofuran-5-yl]methanesulfonamide