N-(3-(5-(2-((3-chloro-4-((2-(dimethylamino)ethyl)oxy)phenyl)amino)-4-pyrimidinyl)-2-(4-methyl-1-piperazinyl)-1,3-thiazol-4-yl)phenyl)-2,6-difluorobenzamide

Base Information

Chemical Name:N-(3-(5-(2-((3-chloro-4-((2-(dimethylamino)ethyl)oxy)phenyl)amino)-4-pyrimidinyl)-2-(4-methyl-1-piperazinyl)-1,3-thiazol-4-yl)phenyl)-2,6-difluorobenzamide
CAS No.:1160623-74-4
Molecular Formula:C₃₅H₃₅ClF₂N₈O₂S
Molecular Weight:705.231
Hs Code.:

N-(3-(5-(2-((3-chloro-4-((2-(dimethylamino)ethyl)oxy)phenyl)amino)-4-pyrimidinyl)-2-(4-methyl-1-piperazinyl)-1,3-thiazol-4-yl)phenyl)-2,6-difluorobenzamide

Synonyms:N-(3-(5-(2-((3-chloro-4-((2-(dimethylamino)ethyl)oxy)phenyl)amino)-4-pyrimidinyl)-2-(4-methyl-1-piperazinyl)-1,3-thiazol-4-yl)phenyl)-2,6-difluorobenzamide

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Chemical Property of N-(3-(5-(2-((3-chloro-4-((2-(dimethylamino)ethyl)oxy)phenyl)amino)-4-pyrimidinyl)-2-(4-methyl-1-piperazinyl)-1,3-thiazol-4-yl)phenyl)-2,6-difluorobenzamide

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Technology Process of N-(3-(5-(2-((3-chloro-4-((2-(dimethylamino)ethyl)oxy)phenyl)amino)-4-pyrimidinyl)-2-(4-methyl-1-piperazinyl)-1,3-thiazol-4-yl)phenyl)-2,6-difluorobenzamide

There total 1 articles about N-(3-(5-(2-((3-chloro-4-((2-(dimethylamino)ethyl)oxy)phenyl)amino)-4-pyrimidinyl)-2-(4-methyl-1-piperazinyl)-1,3-thiazol-4-yl)phenyl)-2,6-difluorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 895636-40-5
{2-[(4-amino-2-chlorophenyl)oxy]ethyl}dimethylamine

: 1160623-75-5
N-(3-(5-(2-chloro-4-pyrimidinyl)-2-(4-methyl-1-piperazinyl)-1,3-thiazol-4-yl)phenyl)-2,6-difluorobenzamide

: 1160623-74-4
N-(3-(5-(2-((3-chloro-4-((2-(dimethylamino)ethyl)oxy)phenyl)amino)-4-pyrimidinyl)-2-(4-methyl-1-piperazinyl)-1,3-thiazol-4-yl)phenyl)-2,6-difluorobenzamide

Guidance literature:: {2-[(4-amino-2-chlorophenyl)oxy]ethyl}dimethylamine; N-(3-(5-(2-chloro-4-pyrimidinyl)-2-(4-methyl-1-piperazinyl)-1,3-thiazol-4-yl)phenyl)-2,6-difluorobenzamide; With hydrogenchloride; In 1,4-dioxane; isopropyl alcohol; at 90 ℃; for 72h;

With triethylamine; In tetrahydrofuran; 1,4-dioxane;