N-(3-(5-(2-chloro-4-pyrimidinyl)-2-(4-methyl-1-piperazinyl)-1,3-thiazol-4-yl)phenyl)-2,6-difluorobenzamide

Base Information

Chemical Name:N-(3-(5-(2-chloro-4-pyrimidinyl)-2-(4-methyl-1-piperazinyl)-1,3-thiazol-4-yl)phenyl)-2,6-difluorobenzamide
CAS No.:1160623-75-5
Molecular Formula:C₂₅H₂₁ClF₂N₆OS
Molecular Weight:526.997
Hs Code.:

Synonyms:N-(3-(5-(2-chloro-4-pyrimidinyl)-2-(4-methyl-1-piperazinyl)-1,3-thiazol-4-yl)phenyl)-2,6-difluorobenzamide

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Chemical Property of N-(3-(5-(2-chloro-4-pyrimidinyl)-2-(4-methyl-1-piperazinyl)-1,3-thiazol-4-yl)phenyl)-2,6-difluorobenzamide

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Technology Process of N-(3-(5-(2-chloro-4-pyrimidinyl)-2-(4-methyl-1-piperazinyl)-1,3-thiazol-4-yl)phenyl)-2,6-difluorobenzamide

There total 1 articles about N-(3-(5-(2-chloro-4-pyrimidinyl)-2-(4-methyl-1-piperazinyl)-1,3-thiazol-4-yl)phenyl)-2,6-difluorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 33860-28-5
4-methylpiperazine-1-carbothioamide

: 1160626-44-7
C₁₉H₁₁BrClF₂N₃O₂

: 1160623-75-5
N-(3-(5-(2-chloro-4-pyrimidinyl)-2-(4-methyl-1-piperazinyl)-1,3-thiazol-4-yl)phenyl)-2,6-difluorobenzamide

Guidance literature:: In 1,4-dioxane; at 50 ℃; for 13h;

Reference yield: 70.0%

: 1160623-75-5
N-(3-(5-(2-chloro-4-pyrimidinyl)-2-(4-methyl-1-piperazinyl)-1,3-thiazol-4-yl)phenyl)-2,6-difluorobenzamide

: 183365-31-3
3‐(pyrrolidin‐1‐ylmethyl)aniline

: 1160623-76-6
2,6-difluoro-N-(3-(2-(4-methyl-1-piperazinyl)-5-(2-((3-(1-pyrrolidinylmethyl)phenyl)amino)-4-pyrimidinyl)-1,3-thiazol-4-yl)phenyl)benzamide

Guidance literature:: N-(3-(5-(2-chloro-4-pyrimidinyl)-2-(4-methyl-1-piperazinyl)-1,3-thiazol-4-yl)phenyl)-2,6-difluorobenzamide; 3‐(pyrrolidin‐1‐ylmethyl)aniline; With hydrogenchloride; In 1,4-dioxane; isopropyl alcohol; at 90 ℃; for 48h;

With triethylamine; In 1,4-dioxane; isopropyl alcohol;

Reference yield: 52.0%

: 895636-40-5
{2-[(4-amino-2-chlorophenyl)oxy]ethyl}dimethylamine

: 1160623-75-5
N-(3-(5-(2-chloro-4-pyrimidinyl)-2-(4-methyl-1-piperazinyl)-1,3-thiazol-4-yl)phenyl)-2,6-difluorobenzamide

: 1160623-74-4
N-(3-(5-(2-((3-chloro-4-((2-(dimethylamino)ethyl)oxy)phenyl)amino)-4-pyrimidinyl)-2-(4-methyl-1-piperazinyl)-1,3-thiazol-4-yl)phenyl)-2,6-difluorobenzamide

Guidance literature:: {2-[(4-amino-2-chlorophenyl)oxy]ethyl}dimethylamine; N-(3-(5-(2-chloro-4-pyrimidinyl)-2-(4-methyl-1-piperazinyl)-1,3-thiazol-4-yl)phenyl)-2,6-difluorobenzamide; With hydrogenchloride; In 1,4-dioxane; isopropyl alcohol; at 90 ℃; for 72h;

With triethylamine; In tetrahydrofuran; 1,4-dioxane;