(2,2-Difluorovinyl)diphenylphosphine

Base Information

Chemical Name:(2,2-Difluorovinyl)diphenylphosphine
CAS No.:241495-61-4
Molecular Formula:C₁₄H₁₁F₂P
Molecular Weight:248.212
Hs Code.:
DSSTox Substance ID:DTXSID601284603
Nikkaji Number:J1.161.917G

Synonyms:DTXSID601284603;(2,2-Difluorovinyl)diphenylphosphine;(2,2-Difluoroethenyl)diphenylphosphine;241495-61-4

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2,2-Difluorovinyl)diphenylphosphine

Chemical Property:

XLogP3:3.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:248.05664367
Heavy Atom Count:17
Complexity:231

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C=C1)P(C=C(F)F)C2=CC=CC=C2

Technology Process of (2,2-Difluorovinyl)diphenylphosphine

There total 3 articles about (2,2-Difluorovinyl)diphenylphosphine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 241495-60-3
diphenyl(2,2,2-trifluoroethyl)phosphine

: 241495-61-4
(2,2-difluorovinyl)diphenylphosphine

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; at -78 ℃; for 0.5h;
DOI:10.1016/S0022-1139(99)00037-8

Reference yield:

: 400846-15-3
PPh₂(CCl=CF₂)

: ((E)-2-Fluoro-vinyl)-diphenyl-phosphane

: 241495-61-4
(2,2-difluorovinyl)diphenylphosphine

: (1-chloro-vinyl)-diphenyl-phosphane

: ((E)-1-Chloro-2-fluoro-vinyl)-diphenyl-phosphane

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; at 20 ℃; Further byproducts given. Title compound not separated from byproducts;
DOI:10.1039/b316099h

Reference yield:

: 829-85-6
diphenylphosphane

: 241495-61-4
(2,2-difluorovinyl)diphenylphosphine

Guidance literature:: Multi-step reaction with 2 steps

1.1: BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

1.2: 83 percent / tetrahydrofuran; hexane / 2 h / -78 °C

2.1: 75 percent / tert-BuOK / tetrahydrofuran / 0.5 h / -78 °C

With n-butyllithium; potassium tert-butylate; In tetrahydrofuran; hexane; 1.1: Metallation / 1.2: Substitution / 2.1: Dehydrofluorination;
DOI:10.1016/S0022-1139(99)00037-8