Ethyl 2-amino-5-chloro-3-hydroxybenzoate

Base Information

Chemical Name:Ethyl 2-amino-5-chloro-3-hydroxybenzoate
CAS No.:365462-85-7
Molecular Formula:C₉H₁₀ClNO₃
Molecular Weight:215.636
Hs Code.:
European Community (EC) Number:868-532-3

Synonyms:ethyl 2-amino-5-chloro-3-hydroxybenzoate;365462-85-7;SCHEMBL5409626;VAMBURGWOHFXGE-UHFFFAOYSA-N;DB-187257;EN300-5511054

Suppliers and Price of Ethyl 2-amino-5-chloro-3-hydroxybenzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of Ethyl 2-amino-5-chloro-3-hydroxybenzoate

Chemical Property:

XLogP3:2.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:215.0349209
Heavy Atom Count:14
Complexity:212

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)C1=C(C(=CC(=C1)Cl)O)N

Technology Process of Ethyl 2-amino-5-chloro-3-hydroxybenzoate

There total 2 articles about Ethyl 2-amino-5-chloro-3-hydroxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.4%

: 606-13-3
ethyl 2-amino-3-hydroxybenzoate

: 365462-85-7
ethyl 2-amino-5-chloro-3-hydroxybenzoate

Guidance literature:: With N-chloro-succinimide; In N,N-dimethyl-formamide; at 50 ℃; for 1.5h;
DOI:10.1016/j.bmc.2014.11.042

Reference yield:

: 548-93-6
3-hydroxyanthranilic acid

: 365462-85-7
ethyl 2-amino-5-chloro-3-hydroxybenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: sulfuric acid / 30 h / Cooling with ice; Reflux

2: N-chloro-succinimide / N,N-dimethyl-formamide / 1 h / 60 °C

With N-chloro-succinimide; sulfuric acid; In N,N-dimethyl-formamide;