1-(1,1-dimethylethyl) 2-methyl (2R,5S)-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-methyl-1,2-pyrrolidinedicarboxylate

Base Information

• Chemical Name: 1-(1,1-dimethylethyl) 2-methyl (2R,5S)-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-methyl-1,2-pyrrolidinedicarboxylate
• CAS No.: 1195787-91-7
• Molecular Formula: C₃₇H₄₀F₇N₃O₅
• Molecular Weight: 739.731
• Mol file: 1195787-91-7.mol

Synonyms:1-(1,1-dimethylethyl) 2-methyl (2R,5S)-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-methyl-1,2-pyrrolidinedicarboxylate

Chemical Property of 1-(1,1-dimethylethyl) 2-methyl (2R,5S)-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-methyl-1,2-pyrrolidinedicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(1,1-dimethylethyl) 2-methyl (2R,5S)-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-methyl-1,2-pyrrolidinedicarboxylate

There total 1 articles about 1-(1,1-dimethylethyl) 2-methyl (2R,5S)-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-methyl-1,2-pyrrolidinedicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 4.58%

1-(1,1-dimethylethyl) 2-methyl (2R,5S)-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-1,2-pyrrolidinedicarboxylate (1195787-89-3) + methyl iodide (74-88-4) → 1-(1,1-dimethylethyl) 2-methyl (2S,5S)-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-methyl-1,2-pyrrolidinedicarboxylate (1195787-90-6) + 1-(1,1-dimethylethyl) 2-methyl (2R,5S)-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-methyl-1,2-pyrrolidinedicarboxylate (1195787-91-7)

Guidance literature:

1-(1,1-dimethylethyl) 2-methyl (2R,5S)-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-1,2-pyrrolidinedicarboxylate; With lithium hexamethyldisilazane; In tetrahydrofuran; hexanes; at -78 - -30 ℃;

methyl iodide; In tetrahydrofuran; hexanes; at -78 ℃; for 1h;

Reference yield: 91.0%

1-(1,1-dimethylethyl) 2-methyl (2R,5S)-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-methyl-1,2-pyrrolidinedicarboxylate (1195787-91-7) → methyl (5S)-5-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-methyl-D-prolinate (1195787-92-8)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2.5h;

Reference yield:

1-(1,1-dimethylethyl) 2-methyl (2R,5S)-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-methyl-1,2-pyrrolidinedicarboxylate (1195787-91-7) → (5S)-5-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-methyl-D-prolinamide (1195787-60-0)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 2.5 h / 20 °C

2: ammonia / methanol / 48 h / 50 °C

With ammonia; trifluoroacetic acid; In methanol; dichloromethane;

upstream raw materials:

1-(1,1-dimethylethyl) 2-methyl (2R,5S)-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-1,2-pyrrolidinedicarboxylate

methyl iodide

Downstream raw materials:

methyl (5S)-5-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-methyl-D-prolinate

(5S)-5-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-methyl-D-prolinamide

(5S)-5-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-methyl-D-prolinamide hydrochloride