4-(Dimethylamino)-2,6-difluorobenzaldehyde

Base Information

Chemical Name:4-(Dimethylamino)-2,6-difluorobenzaldehyde
CAS No.:736991-10-9
Molecular Formula:C₉H₉F₂NO
Molecular Weight:185.173
Hs Code.:
DSSTox Substance ID:DTXSID601267043

Synonyms:736991-10-9;4-(dimethylamino)-2,6-difluorobenzaldehyde;Benzaldehyde, 4-(dimethylamino)-2,6-difluoro-;SCHEMBL3176222;QCYVIXVSXYXYPT-UHFFFAOYSA-N;DTXSID601267043;4-dimethlyamino-2,6-difluorobenzaldehyde

Suppliers and Price of 4-(Dimethylamino)-2,6-difluorobenzaldehyde

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(Dimethylamino)-2,6-difluorobenzaldehyde

Chemical Property:

XLogP3:1.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:185.06522023
Heavy Atom Count:13
Complexity:175

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CN(C)C1=CC(=C(C(=C1)F)C=O)F

Technology Process of 4-(Dimethylamino)-2,6-difluorobenzaldehyde

There total 2 articles about 4-(Dimethylamino)-2,6-difluorobenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 123855-25-4
3,5-difluoro-N,N-dimethylaniline

: 736991-10-9
2,6-difluoro-4-dimethylaminobenzaldehyde

Guidance literature:: With potassium carbonate; In acetone; at 60 ℃; for 5h;
DOI:10.1021/jm950639r

Reference yield:

: 372-39-4
3,5-difluoroaniline

: 736991-10-9
2,6-difluoro-4-dimethylaminobenzaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: 2.) NaOH / 1.) 180 deg C, 2 h, 2.) H₂O, 1 h, reflux

2: K₂CO₃ / acetone / 5 h / 60 °C

With sodium hydroxide; potassium carbonate; In acetone;
DOI:10.1021/jm950639r