1-(3-fluoro-cis-3-methylcyclobutyl)-3-(2-fluoro-4-methyl-5-(2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl)phenyl)urea

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Chemical Name:1-(3-fluoro-cis-3-methylcyclobutyl)-3-(2-fluoro-4-methyl-5-(2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl)phenyl)urea
CAS No.:1455032-62-8
Molecular Formula:C₂₃H₂₅F₂N₅O
Molecular Weight:425.481
Hs Code.:

Synonyms:1-(3-fluoro-cis-3-methylcyclobutyl)-3-(2-fluoro-4-methyl-5-(2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl)phenyl)urea

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Chemical Property of 1-(3-fluoro-cis-3-methylcyclobutyl)-3-(2-fluoro-4-methyl-5-(2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl)phenyl)urea

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Technology Process of 1-(3-fluoro-cis-3-methylcyclobutyl)-3-(2-fluoro-4-methyl-5-(2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl)phenyl)urea

There total 3 articles about 1-(3-fluoro-cis-3-methylcyclobutyl)-3-(2-fluoro-4-methyl-5-(2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl)phenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1455037-43-0,1613330-60-1
3-methyl-trans(3-fluorocyclobutanecarboxylic acid)

: 1455036-26-6
3-(5-amino-4-fluoro-2-methyl-phenyl)-N, 2-dimethyl-1,6-naphthyridin-7-amine

: 1455032-62-8
1-(3-fluoro-cis-3-methylcyclobutyl)-3-(2-fluoro-4-methyl-5-(2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl)phenyl)urea

Guidance literature:: 3-methyl-trans(3-fluorocyclobutanecarboxylic acid); With diphenyl phosphoryl azide; triethylamine; In 1,4-dioxane; at 80 ℃;

3-(5-amino-4-fluoro-2-methyl-phenyl)-N, 2-dimethyl-1,6-naphthyridin-7-amine; In 1,4-dioxane; at 50 ℃;

Reference yield:

: benzyl 3-hydroxy-3-methylcyclobutanecarboxylate

: 1455032-62-8
1-(3-fluoro-cis-3-methylcyclobutyl)-3-(2-fluoro-4-methyl-5-(2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl)phenyl)urea

Guidance literature:: Multi-step reaction with 3 steps

1.1: diethylamino-sulfur trifluoride / dichloromethane / -78 - 20 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / methanol / 760.05 Torr

3.1: diphenyl phosphoryl azide; triethylamine / 1,4-dioxane / 80 °C

3.2: 50 °C

With diethylamino-sulfur trifluoride; diphenyl phosphoryl azide; palladium 10% on activated carbon; hydrogen; triethylamine; In 1,4-dioxane; methanol; dichloromethane; 3.1: |Curtius Rearrangement / 3.2: |Curtius Rearrangement;

Reference yield:

: 1455037-41-8
benzyl 3-methyl-trans(3-fluorocyclobutanecarboxylate)

: 1455032-62-8
1-(3-fluoro-cis-3-methylcyclobutyl)-3-(2-fluoro-4-methyl-5-(2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl)phenyl)urea

Guidance literature:: Multi-step reaction with 2 steps

1.1: palladium 10% on activated carbon; hydrogen / methanol / 760.05 Torr

2.1: diphenyl phosphoryl azide; triethylamine / 1,4-dioxane / 80 °C

2.2: 50 °C

With diphenyl phosphoryl azide; palladium 10% on activated carbon; hydrogen; triethylamine; In 1,4-dioxane; methanol; 2.1: |Curtius Rearrangement / 2.2: |Curtius Rearrangement;