3-(5-amino-4-fluoro-2-methyl-phenyl)-N, 2-dimethyl-1,6-naphthyridin-7-amine

Base Information

Chemical Name:3-(5-amino-4-fluoro-2-methyl-phenyl)-N, 2-dimethyl-1,6-naphthyridin-7-amine
CAS No.:1455036-26-6
Molecular Formula:C₁₇H₁₇FN₄
Molecular Weight:296.347
Hs Code.:

Synonyms:3-(5-amino-4-fluoro-2-methyl-phenyl)-N, 2-dimethyl-1,6-naphthyridin-7-amine

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Chemical Property of 3-(5-amino-4-fluoro-2-methyl-phenyl)-N, 2-dimethyl-1,6-naphthyridin-7-amine

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Technology Process of 3-(5-amino-4-fluoro-2-methyl-phenyl)-N, 2-dimethyl-1,6-naphthyridin-7-amine

There total 13 articles about 3-(5-amino-4-fluoro-2-methyl-phenyl)-N, 2-dimethyl-1,6-naphthyridin-7-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 452-63-1
2-Bromo-5-fluorotoluene

: 1455036-26-6
3-(5-amino-4-fluoro-2-methyl-phenyl)-N, 2-dimethyl-1,6-naphthyridin-7-amine

Guidance literature:: Multi-step reaction with 5 steps

1: nitric acid; sulfuric acid / 0.83 h / -5 - 20 °C

2: hydrogen / ethanol / 2062.71 Torr

3: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 100 °C / Inert atmosphere

4: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water / 1 h / 60 °C / Inert atmosphere

5: ethanol / 7 h / 154 °C / Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sulfuric acid; hydrogen; nitric acid; potassium acetate; potassium carbonate; In 1,4-dioxane; ethanol; water;
DOI:10.1021/acs.jmedchem.5b00067

Reference yield:

: 1001756-21-3
4-amino-6-chloropyridine-3-carboxaldehyde

: 1455036-26-6
3-(5-amino-4-fluoro-2-methyl-phenyl)-N, 2-dimethyl-1,6-naphthyridin-7-amine

Guidance literature:: Multi-step reaction with 4 steps

1: potassium hydroxide / tetrahydrofuran / 1 h / 20 °C

2: pyridine / dichloromethane / 2 h / 0 °C / Inert atmosphere

3: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water / 1 h / 60 °C / Inert atmosphere

4: ethanol / 7 h / 154 °C / Microwave irradiation

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; potassium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.1021/acs.jmedchem.5b00067

Reference yield:

: 1455035-96-7
7-chloro-2-methyl[1,6]naphthyridin-3-yl trifluoromethanesulfonate

: 1455036-26-6
3-(5-amino-4-fluoro-2-methyl-phenyl)-N, 2-dimethyl-1,6-naphthyridin-7-amine

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water / 1 h / 60 °C / Inert atmosphere

2: ethanol / 7 h / 154 °C / Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In ethanol; water;
DOI:10.1021/acs.jmedchem.5b00067