(3R)-tert-butyl 3-(4-(3-(4-chlorobenzoyl)-4,5-dimethylthiophen-2yl)-3-methylisoxazol-5-yl)-3-((R)-1,1-dimethylethylsulfinamido)propanoate

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Chemical Name:(3R)-tert-butyl 3-(4-(3-(4-chlorobenzoyl)-4,5-dimethylthiophen-2yl)-3-methylisoxazol-5-yl)-3-((R)-1,1-dimethylethylsulfinamido)propanoate
CAS No.:1380089-53-1
Molecular Formula:C₂₈H₃₅ClN₂O₅S₂
Molecular Weight:579.181
Hs Code.:

Synonyms:(3R)-tert-butyl 3-(4-(3-(4-chlorobenzoyl)-4,5-dimethylthiophen-2yl)-3-methylisoxazol-5-yl)-3-((R)-1,1-dimethylethylsulfinamido)propanoate

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Chemical Property of (3R)-tert-butyl 3-(4-(3-(4-chlorobenzoyl)-4,5-dimethylthiophen-2yl)-3-methylisoxazol-5-yl)-3-((R)-1,1-dimethylethylsulfinamido)propanoate

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Technology Process of (3R)-tert-butyl 3-(4-(3-(4-chlorobenzoyl)-4,5-dimethylthiophen-2yl)-3-methylisoxazol-5-yl)-3-((R)-1,1-dimethylethylsulfinamido)propanoate

There total 10 articles about (3R)-tert-butyl 3-(4-(3-(4-chlorobenzoyl)-4,5-dimethylthiophen-2yl)-3-methylisoxazol-5-yl)-3-((R)-1,1-dimethylethylsulfinamido)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 321745-86-2
2-tert-butoxy-2-oxoethylzinc chloride

: 1380089-52-0
(R,E)-N-((4-(3-(4-chlorobenzoyl)-4,5-dimethylthiophen-2-yl)-3-methylisoxazol-5-yl)methylene)-2-methylpropane-2-sulfinamide

: 1380089-53-1
(3R)-tert-butyl 3-(4-(3-(4-chlorobenzoyl)-4,5-dimethylthiophen-2yl)-3-methylisoxazol-5-yl)-3-((R)-1,1-dimethylethylsulfinamido)propanoate

: (3S)-tert-butyl 3-(4-(3-(4-chlorobenzoyl)-4,5-dimethylthiophen-2yl)-3-methylisoxazol-5-yl)-3-((R)-1,1-dimethylethylsulfinamido)propanoate

Guidance literature:: In tetrahydrofuran; at 0 ℃;

Reference yield:

: 14559-13-8
methyl 4,5-dimethylthiophene-3-carboxylate

: 1380089-53-1
(3R)-tert-butyl 3-(4-(3-(4-chlorobenzoyl)-4,5-dimethylthiophen-2yl)-3-methylisoxazol-5-yl)-3-((R)-1,1-dimethylethylsulfinamido)propanoate

Guidance literature:: Multi-step reaction with 7 steps

1: isopropylmagnesium bromide / tetrahydrofuran; cyclopentyl methyl ether / -20 - 0 °C

2: diethyl ether; tetrahydrofuran / 0.17 h / -40 °C

3: N-Bromosuccinimide / N,N-dimethyl-formamide / 2 h

4: potassium carbonate; water / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 5 h / 95 °C / Inert atmosphere

5: oxalyl dichloride / dimethyl sulfoxide / dichloromethane / 0.75 h / -78 °C

6: titanium(IV) ethoxide / dichloromethane / 24 h

7: tetrahydrofuran / 0 °C

With N-Bromosuccinimide; oxalyl dichloride; water; isopropylmagnesium bromide; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; titanium(IV) ethoxide; dimethyl sulfoxide; In tetrahydrofuran; diethyl ether; dichloromethane; cyclopentyl methyl ether; N,N-dimethyl-formamide;

Reference yield:

: 1380089-50-8
(2-bromo-4,5-dimethylthiophen-3-yl)(4-chlorophenyl)methanone

: 1380089-53-1
(3R)-tert-butyl 3-(4-(3-(4-chlorobenzoyl)-4,5-dimethylthiophen-2yl)-3-methylisoxazol-5-yl)-3-((R)-1,1-dimethylethylsulfinamido)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate; water / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 5 h / 95 °C / Inert atmosphere

2: oxalyl dichloride / dimethyl sulfoxide / dichloromethane / 0.75 h / -78 °C

3: titanium(IV) ethoxide / dichloromethane / 24 h

4: tetrahydrofuran / 0 °C

With oxalyl dichloride; water; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; titanium(IV) ethoxide; dimethyl sulfoxide; In tetrahydrofuran; dichloromethane;