N-[(R)-1-[(1,1-dimethylethoxy)carbonyl]-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]propyl]-L-leucine

Base Information

Chemical Name:N-[(R)-1-[(1,1-dimethylethoxy)carbonyl]-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]propyl]-L-leucine
CAS No.:149967-11-3
Molecular Formula:C₂₀H₄₁NO₅Si
Molecular Weight:403.635
Hs Code.:

Synonyms:N-[(R)-1-[(1,1-dimethylethoxy)carbonyl]-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]propyl]-L-leucine

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Chemical Property of N-[(R)-1-[(1,1-dimethylethoxy)carbonyl]-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]propyl]-L-leucine

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Technology Process of N-[(R)-1-[(1,1-dimethylethoxy)carbonyl]-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]propyl]-L-leucine

There total 1 articles about N-[(R)-1-[(1,1-dimethylethoxy)carbonyl]-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]propyl]-L-leucine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 20312-37-2,498-36-2
(R)-2-hydroxy-4-methylpentanoic acid

: 149967-11-3
N-[(R)-1-[(1,1-dimethylethoxy)carbonyl]-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]propyl]-L-leucine

Guidance literature:: Multi-step reaction with 3 steps

1: dimethylformamide / 18 h / 23 °C

2: 1.) trifluoromethanesulfonic anhydride, 1,8-bis(dimethylamino)naphthalene / 1.) CH₂Cl₂, 0 deg C, 30 min, 2.) CH₂Cl₂, dioxane, 21 deg C, 15 h

3: 100 percent / H₂ / 10percent Pd/C / ethanol / 2 h / 2068.6 Torr

With hydrogen; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; trifluoromethanesulfonic acid anhydride; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00031a018

Reference yield: 43.0%

: 35373-92-3
L-phenylalanine methylamide

: 149967-11-3
N-[(R)-1-[(1,1-dimethylethoxy)carbonyl]-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]propyl]-L-leucine

: -3-<<(1,1-dimethylethyl)dimethylsilyl>oxy>propyl>-L-leucyl>-N-methyl-L-phenylalaninamide

Guidance literature:: With 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 21 ℃; for 15h;
DOI:10.1021/jm00031a018

Reference yield:

: 149967-11-3
N-[(R)-1-[(1,1-dimethylethoxy)carbonyl]-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]propyl]-L-leucine

: -3-aminopropyl>-L-leucyl>-N-methyl-L-phenylalaninamide

Guidance literature:: Multi-step reaction with 4 steps

1: 43 percent / 1-hydroxybenzotriazole hydrate, dicyclohexylcarbodiimide / dimethylformamide / 15 h / 21 °C

2: 91 percent / aq. HOAc / 15 h / 5 °C

3: 35 percent / triphenylphosphine, diethyl azodicarboxylate / tetrahydrofuran / 16 h / 23 °C

4: 76 percent / H₂ / 10percent Pd/C / methanol / 19 h

With hydrogen; acetic acid; 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00031a018