(2R)-4-[4-(2-chloro-4-methoxyphenyl)-1H-1,2,3-triazol-1-yl]-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide

Base Information

Chemical Name:(2R)-4-[4-(2-chloro-4-methoxyphenyl)-1H-1,2,3-triazol-1-yl]-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide
CAS No.:1402636-67-2
Molecular Formula:C₁₅H₁₉ClN₄O₅S
Molecular Weight:402.859
Hs Code.:

Synonyms:(2R)-4-[4-(2-chloro-4-methoxyphenyl)-1H-1,2,3-triazol-1-yl]-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide

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Chemical Property of (2R)-4-[4-(2-chloro-4-methoxyphenyl)-1H-1,2,3-triazol-1-yl]-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide

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Technology Process of (2R)-4-[4-(2-chloro-4-methoxyphenyl)-1H-1,2,3-triazol-1-yl]-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide

There total 5 articles about (2R)-4-[4-(2-chloro-4-methoxyphenyl)-1H-1,2,3-triazol-1-yl]-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1402636-66-1
(2R)-4-[4-(2-chloro-4-methoxyphenyl)-1H-1,2,3-triazol-1-yl]-2-methyl-2-(methylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide

: 1402636-67-2
(2R)-4-[4-(2-chloro-4-methoxyphenyl)-1H-1,2,3-triazol-1-yl]-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide

Guidance literature:: With hydrogenchloride; In ethanol; water; at 20 ℃; for 3h;

Reference yield:

: 1402636-06-9
(2R)-4-azido-2-methyl-2-(methylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide

: 1402636-67-2
(2R)-4-[4-(2-chloro-4-methoxyphenyl)-1H-1,2,3-triazol-1-yl]-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide

Guidance literature:: Multi-step reaction with 2 steps

1: copper(II) sulfate; L-ascorbic acid sodium salt / ethanol; water / 20 °C

2: hydrogenchloride / ethanol; water / 3 h / 20 °C

With hydrogenchloride; L-ascorbic acid sodium salt; copper(II) sulfate; In ethanol; water; 1: Azide alkyne Huisgen cycloaddition;

Reference yield:

: 1312478-48-0
(2R)-ethyl 4-bromo-2-methyl-2-(methylsulfonyl)butanoate

: 1402636-67-2
(2R)-4-[4-(2-chloro-4-methoxyphenyl)-1H-1,2,3-triazol-1-yl]-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium azide / dimethyl sulfoxide / 3 h / 80 °C

2.1: water; lithium hydroxide / 16 h / 80 °C

3.1: 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine / tetrahydrofuran / 3 h / 20 °C

3.2: 16 h

4.1: copper(II) sulfate; L-ascorbic acid sodium salt / ethanol; water / 20 °C

5.1: hydrogenchloride / ethanol; water / 3 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; sodium azide; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; L-ascorbic acid sodium salt; water; copper(II) sulfate; lithium hydroxide; In tetrahydrofuran; ethanol; water; dimethyl sulfoxide; 4.1: Azide alkyne Huisgen cycloaddition;