N-α-tert-butoxycarbonyl-γ-benzyl ester L-glutamyl-L-methionine ethyl ester

Base Information

Chemical Name:N-α-tert-butoxycarbonyl-γ-benzyl ester L-glutamyl-L-methionine ethyl ester
CAS No.:1330059-40-9
Molecular Formula:C₂₃H₃₄N₂O₇S
Molecular Weight:482.598
Hs Code.:

Synonyms:N-α-tert-butoxycarbonyl-γ-benzyl ester L-glutamyl-L-methionine ethyl ester

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Chemical Property of N-α-tert-butoxycarbonyl-γ-benzyl ester L-glutamyl-L-methionine ethyl ester

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Technology Process of N-α-tert-butoxycarbonyl-γ-benzyl ester L-glutamyl-L-methionine ethyl ester

There total 4 articles about N-α-tert-butoxycarbonyl-γ-benzyl ester L-glutamyl-L-methionine ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1186060-38-7
Boc-L-Glu(OBn)-SH

: 2491-18-1
(S)-methyl 2-amino-4-(methylthio)butanoate hydrochloride

: 1330059-40-9
N-α-tert-butoxycarbonyl-γ-benzyl ester L-glutamyl-L-methionine ethyl ester

Guidance literature:: With N,O-bis-(trimethylsilyl)-acetamide; triethylamine; In tetrahydrofuran; at 20 ℃; for 10h;
DOI:10.1021/ja2065158

Reference yield: 68.0%

: 1330059-40-9
N-α-tert-butoxycarbonyl-γ-benzyl ester L-glutamyl-L-methionine ethyl ester

Guidance literature:: With piperidine; In N,N-dimethyl-formamide;

With hydrogenchloride;

With N,O-bis-(trimethylsilyl)-acetamide; In tetrahydrofuran; at 20 ℃; for 10h;

Reference yield:

: 13574-13-5
Boc-Glu(OBzl)-OH

: 1330059-40-9
N-α-tert-butoxycarbonyl-γ-benzyl ester L-glutamyl-L-methionine ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 0 - 20 °C

2: piperidine / N,N-dimethyl-formamide / 1 h / 20 °C

3: N,O-bis-(trimethylsilyl)-acetamide; triethylamine / tetrahydrofuran / 10 h / 20 °C

With piperidine; dmap; N,O-bis-(trimethylsilyl)-acetamide; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja2065158