ethyl (E)-3-[4-(4-bromo-benzylamino)-2,6-bis(methoxymethyl)-5-pyrimidinyl]-2-propenoate

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Chemical Name:ethyl (E)-3-[4-(4-bromo-benzylamino)-2,6-bis(methoxymethyl)-5-pyrimidinyl]-2-propenoate
CAS No.:499775-93-8
Molecular Formula:C₂₀H₂₄BrN₃O₄
Molecular Weight:450.332
Hs Code.:

Synonyms:ethyl (E)-3-[4-(4-bromo-benzylamino)-2,6-bis(methoxymethyl)-5-pyrimidinyl]-2-propenoate

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Chemical Property of ethyl (E)-3-[4-(4-bromo-benzylamino)-2,6-bis(methoxymethyl)-5-pyrimidinyl]-2-propenoate

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Technology Process of ethyl (E)-3-[4-(4-bromo-benzylamino)-2,6-bis(methoxymethyl)-5-pyrimidinyl]-2-propenoate

There total 5 articles about ethyl (E)-3-[4-(4-bromo-benzylamino)-2,6-bis(methoxymethyl)-5-pyrimidinyl]-2-propenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 3959-07-7
4-Bromobenzylamine

: 499775-92-7
ethyl (E)-3-[4-chloro-2,6-bis(methoxymethyl)-5-pyrimidinyl]-2-propenoate

: 499775-93-8
ethyl (E)-3-[4-(4-bromo-benzylamino)-2,6-bis(methoxymethyl)-5-pyrimidinyl]-2-propenoate

Guidance literature:: With triethylamine; In butan-1-ol; for 2h; Heating;
DOI:10.1016/S0960-894X(02)00303-7

Reference yield:

: 41051-15-4
4-methoxyacetoacetic acid methylester

: 499775-93-8
ethyl (E)-3-[4-(4-bromo-benzylamino)-2,6-bis(methoxymethyl)-5-pyrimidinyl]-2-propenoate

Guidance literature:: Multi-step reaction with 5 steps

1: 85 percent / NaOEt / ethanol / 4 h / Heating

2: 3.3 g / I₂; K₂CO₃ / tetrahydrofuran / 6 h / Heating

3: 64 percent / Et₃N / palladium acetate / 0.75 h / 130 °C

4: 67 percent / POCl₃ / benzene / 2 h / Heating

5: 94 percent / Et₃N / butan-1-ol / 2 h / Heating

With iodine; sodium ethanolate; potassium carbonate; triethylamine; trichlorophosphate; palladium diacetate; In tetrahydrofuran; ethanol; butan-1-ol; benzene; 3: Heck reactions;
DOI:10.1016/S0960-894X(02)00303-7

Reference yield:

: 3122-77-8
2,6-bis(methoxymethyl)-4-pyrimidinol

: 499775-93-8
ethyl (E)-3-[4-(4-bromo-benzylamino)-2,6-bis(methoxymethyl)-5-pyrimidinyl]-2-propenoate

Guidance literature:: Multi-step reaction with 4 steps

1: 3.3 g / I₂; K₂CO₃ / tetrahydrofuran / 6 h / Heating

2: 64 percent / Et₃N / palladium acetate / 0.75 h / 130 °C

3: 67 percent / POCl₃ / benzene / 2 h / Heating

4: 94 percent / Et₃N / butan-1-ol / 2 h / Heating

With iodine; potassium carbonate; triethylamine; trichlorophosphate; palladium diacetate; In tetrahydrofuran; butan-1-ol; benzene; 2: Heck reactions;
DOI:10.1016/S0960-894X(02)00303-7